by Newcastle University A Wright’s stained bone marrow aspirate smear of patient with precursor B-cell acute lymphoblastic leukemia. Credit: VashiDonsk/Wikimedia/CC BY-SA 3.0 An international team of scientists has uncovered one of the mechanisms explaining how some leukemias evade treatment by changing their appearance and identity. Most children with the common blood cancer B-cell acute lymphoblastic leukemia (ALL)...
Max Kozlov The fungus Candida — shown here growing under laboratory conditions — has been found in some tumour samples. Credit: Nicolas Armer/dpa/Alamy For years, evidence has been mounting that bacteria are linked to cancer, and sometimes even play a crucial part in its progression. Now, researchers have found a similar connection with another type...
by Brigham and Women’s Hospital Credit: Unsplash/CC0 Public Domain Over recent decades, more and more adults under the age of 50 are developing cancer. A study conducted by researchers from Brigham and Women’s Hospital reveals that the incidence of early onset cancers (those diagnosed before age 50), including cancers of the breast, colon, esophagus, kidney,...
by Dennis Thompson Two experimental vaccines show promise in protecting against infection with the “mono” virus, which also causes cancer and has been implicated as a potential trigger of multiple sclerosis, a new paper reports. Tested only in animals so far, the vaccines block two pathways by which the Epstein-Barr virus(EBV) takes root inside the body,...
by Institute of Cancer Research Fig. 1: Identification of trapped PARP1-interacting proteins. a, Schematic describing the identification of trapped PARP1 protein–protein interactomes via RIME or proximity labeling linked to mass spectrometry. The cells were exposed to either PARPi + MMS (to enable trapping) or MMS (no trapping) for 1 h, after which PARP1-interacting/proximal proteins were identified by mass...
by University of Michigan Credit: Pixabay/CC0 Public Domain While researchers have identified several genes that drive prostate cancer, a new study published in Nature reveals the puppet master controlling the strings. The strings: Cancer-causing genes, or oncogenes, such as androgen receptor, FOXA1, ERG, and MYC. The puppet master: A chromatin remodeling complex called SWI/SNF, which controls the...
by Stanford University Medical Center Credit: CC0 Public Domain Activating the immune system at the site of a tumor can recruit and stimulate immune cells to destroy tumor cells. One strategy involves injecting immune-stimulating molecules directly into the tumor, but this method can be challenging for cancers that are not easily accessible. Now, Stanford researchers have...
IMAGE: (A) WESTERN BLOT ANALYSIS OF MYC IN INDICATED CELL LINES AFTER TRANSFECTION WITH 10 NMOL/L OF MIR-NC OR MIR-766-5P. THE INTENSITY OF MYC BANDS WAS QUANTIFIED BY DENSITOMETRY AND SHOWN AS THE FOLD CHANGE AFTER NORMALIZATION WITH Β-ACTIN. NA, NOT APPLICABLE. (B) WESTERN BLOT ANALYSIS OF CBP AND BRD4 IN HCT116-/- CELLS 48 HOURS...
by Diana Cano Bordajandi, Institute of Cancer Research Credit: Pixabay/CC0 Public Domain “Genomics’ has become a buzzword in recent years, especially as it is increasingly used in the clinic. Proteomics, on the other hand, remains a bit of a mystery to many people. Simply put, genomics is the study of the entire set of genes in a...
by University of Southern California Credit: Unsplash/CC0 Public Domain Brain metastasis occurs when cancer in one part of the body spreads to the brain. The lifetime incidence of such metastatic brain tumors in cancer patients is between 20%-45%, research shows. A new study from USC Norris Comprehensive Cancer Center, part of Keck Medicine of USC, suggests that the...
