by Indiana University Histone H3 lysine 9 (H3K9) acetylation and SPHK2 (sphingosine kinase 2) expression show a potential correlation in pulmonary arterial hypertension (PAH) patients’ lungs. A, Representative immunoblot probed for acetyl-H3K9 (Ac-H3K9), total H3, tubulin, and Ponceau S staining in protein lysates of human idiopathic pulmonary arterial hypertension (iPAH: type of group 1 pulmonary...
by Germans Trias i Pujol Research Institute A) Timeline scheme of the experimental groups and procedures. Effect of (B–E) ischemic stroke and (F–I) intracerebral hemorrhage on (B,F) infarct or hemorrhage volume, (C,G) edema, (D,H) stroke-induced maximum hemispheric midline shift (broken white line) vs. the theoretical midline (solid black line), and (E,I) body weight loss; **...
Sue Hughes November 20, 2023 A single injection of the investigational antihypertensive agent zilebesiran (Alnylam Pharmaceuticals) effectively lowered blood pressure in adults with mild to moderate hypertension for up to 6 months, with what appeared to be an encouraging side-effect profile, in the phase 2 dose-ranging KARDIA-1 study. “Our study demonstrates that either quarterly or...
by Federico Graciano, Duke-NUS Medical School Credit: Unsplash/CC0 Public DomainKeeping blood pressure in check could save lives among Asian adults with type 2 diabetes, suggests a sizable new study of more than 80,000 patients in Singapore. But how low should it go? A new study led by Duke-NUS Medical School, published in the Journal of...
by Angelika Leute, Kompetenznetz Vorhofflimmern e.V. (AFNET) Credit: Pixabay/CC0 Public DomainAtrial high-rate episodes (AHRE) are short and rare atrial arrhythmias that resemble atrial fibrillation detected by implanted pacemakers, defibrillators, and loop recorders that enable long-term monitoring of heart rhythm. AHRE are found in 10–30% of patients with implanted devices. AHRE episodes resemble atrial fibrillation. Therefore,...
Being more physically active could help lower the risk of experiencing a range of cardiovascular events. Antonio_Diaz/Getty Images Atrial fibrillation (AFib) is an abnormal heart rhythm that can harm cardiovascular health.Study findings presented at the ESC Congress 2023 found that higher levels of physical fitness were associated with decreased risk for atrial fibrillation, stroke, and...
Patrick Campbell Conference |European Society of Cardiology CongressJaved Butler, MD, discusses the overall results of the STEP-HFpEF trial, how he interprets the reduction in adjudicated heart failure events, and how the community’s recent experience with SGLT2 inhibitors might inform uptake strategies for semaglutide 2.4 mg. The understanding and management of heart failure with preserved ejection...
First responders with the Ventura County EMS Agency provide Cedars-Sinai investigators with community-based data for the Prediction of Sudden Death in Multi-Ethnic Communities (PRESTO) Study, an effort led by the Smidt Heart Institute to better understand sudden cardiac arrest. Photo courtesy of Ventura County EMS Agency.Smidt Heart Institute Investigators Found That 50% of Individuals Experienced...
by University of Tokyo A new DNA drug to fight blood clots—a potential new and less risky treatment for thrombosisHuman thrombin. Thrombin is the enzyme responsible for bleeding and for blood clotting, depending on how it’s activated, and has two DNA drug-binding sites. Credit: Yoshimoto et al, CC-BYVarious medical circumstances, including heart attacks and extreme...
by National Institutes of Health Credit: CC0 Public Domain It’s a workhorse nutrient that strengthens bones, supports immune function, helps the heart, and powers the body in many other ways. But recent findings about vitamin D are clear: High doses do not improve heart and circulatory health for most adults any more than modest doses do. “It takes only...
