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Newly discovered mutation could point to heart disease therapeutic target
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Newly discovered mutation could point to heart disease therapeutic target

by Carnegie Institution for Science lipid from the yolk of a zebrafish through the circulation to the growing tissues of the embryo. Later in development, they will also carry lipids from the intestine and liver. While normal, wild-type, zebrafish have clear yolks (top image), zebrafish with mutations in Mtp have abnormally opaque yolks because they...

Slowing down a ‘helper’ cell may someday make vaccines more effective for seniors
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Slowing down a ‘helper’ cell may someday make vaccines more effective for seniors

A surprising new concept for boosting the power of flu vaccines might also boost future COVID-19 vaccines CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER UNDESIRED EXCESSIVE INTERLEUKIN-10 (IL-10) PRODUCTION IN AGED MICE COMES PRIMARILY FROM TFH CELLS, ACCORDING TO NEW FINDINGS PUBLISHED IN SCIENCE ADVANCES. THIS CHART SHOWS THAT WHEN THESE CELLS ARE STIMULATED… view more CREDIT:...

New Drug Combo Shows Promise in Fight Against High Cholesterol
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New Drug Combo Shows Promise in Fight Against High Cholesterol

Adding certain drugs to your statin can reduce cholesterol levels better than taking a statin alone. Here, a Michigan Medicine doctor breaks it all down. If you’ve ever been diagnosed with high cholesterol, also known as hyperlipidemia, your doctor has probably prescribed a statin. And while statins have been the go-to drug for managing cholesterol...

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Women taking beta blockers for hypertension may have higher risk of heart failure with acute coronary syndrome

DALLAS, July 13, 2020 — Women taking beta blockers for hypertension with no prior history of cardiovascular disease (CVD) have a nearly 5% higher risk for heart failure than men when they present to hospital with acute coronary syndrome, according to new research published today in Hypertension, an American Heart Association journal. Beta blockers are...

MicroRNA-34a Promotes Vascular Cellular Senescence and Consequent Calcification
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MicroRNA-34a Promotes Vascular Cellular Senescence and Consequent Calcification

With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). The SASP...

The Aging Gut Microbiome Produces More Trimethylamine, Harming Arterial Function
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The Aging Gut Microbiome Produces More Trimethylamine, Harming Arterial Function

In recent years academic interest has grown in the study of the gut microbiome. Researchers are making inroads into understanding the considerable influence of these microbial populations over the progression of health and aging. The gut microbiome may be as influential as physical activity in these matters. The balance of microbial populations shifts unfavorably over...