by Brigham and Women’s Hospital Cancer cells can adapt and develop resistance to chemotherapy drugs, making it difficult to eradicate tumors. A new study led by investigators from Brigham and Women’s Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. The results of the...
Tag: <span>cell biology</span>
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B cells off the rails early in lupus
by Quinn Eastman, Emory University New research on the autoimmune disease systemic lupus erythematosus (SLE) provides hints to the origins of the puzzling disorder. The results were published Monday in Nature Immunology. In people with SLE, their B cells—part of the immune system—are abnormally activated. That makes them produce antibodies that react against their own tissues, causing a variety of symptoms,...
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UH researcher reports the way sickle cells form may be key to stopping them
Process could be similar to how first living cells formed; applications to industry possible UNIVERSITY OF HOUSTON University of Houston associate professor of chemistry, Vassiliy Lubchenko, is reporting a new finding in Nature Communications on how sickle cells are formed. Lubchenko reports that droplets of liquid, enriched in hemoglobin, form clusters inside some red blood cells when two hemoglobin molecules form a bond – but only briefly, for one thousandth...
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Researchers release first 3D model of human cell division
Scientists at the Allen Institute for Cell Science have created what they believe is the first comprehensive 3D model for mitosis using human stem cells. Previous models have characterized proteins involved in cell division using abnormal cells, but project co-director Susanne Rafelski says the Integrated Mitotic Stem Cell project — which includes images from some 2,000 mitotic cells and 15 structures within cells — captures how normal cells behave....
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