Tag: <span>Cell-penetrating peptides (CPPs)</span>

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Membrane perturbation through novel cell-penetrating peptides influences intracellular accumulation of imatinib mesylate in CML cells

Abstract Chronic myeloid leukemia is a stem cell disease with the presence of Philadelphia chromosome generated through reciprocal translocation of chromosome 9 and 22. The use of first- and second-generation tyrosine kinase inhibitors has been successful to an extent. However, resistance against such drugs is an emerging problem. Apart from several drug-resistant mechanisms, drug influx/efflux...

October 31, 2017October 31, 2017by In Cancer
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Small intestine permeable peptides facilitate digestive tract absorption

Changing injected drugs into orally administered medications Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, resulting in a bottleneck for oral administration type biopharmaceutical development. Now, researchers from Kumamoto University in Japan have found a new small intestine permeable peptide...