NEWS RELEASE 12-JUN-2024 Subcutaneous biodegradable scaffolds for restimulating the antitumor activity of preadministered CAR-T cells Peer-Reviewed PublicationWYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD IMAGE: T-CELL ENHANCING SCAFFOLDS CAN BE LOCALLY INJECTED UNDER THE SKIN FOLLOWING CAR-T CELL THERAPY, AND ALLOWCIRCULATING CAR-T CELLS TO INFILTRATE THEIR 3-DIMENSIONAL POROUS SCAFFOLD STRUCTURE. THERE, CAR-T CELLS BECOME ACTIVATED...
mRNA’s next trick? Reprogramming off-the-shelf cell therapies for cancer and autoimmune diseasesRyan CrossSenior Science CorrespondentLei Lei WuNews ReporterA handful of biotechs, including Moderna, are betting that simple infusions with mRNA could supercharge immune cells to fight cancer and other diseases in what would be a fresh take on CAR-T cell therapies.Instead of collecting a patient’s...
A University of Minnesota Twin Cities team has developed a new tool to predict and customize the rate of a specific kind of DNA editing called “site-specific recombination.” The research, recently published in Nature Communications, paves the way for more personalized, efficient genetic and cell therapies for diseases such as diabetes and cancer. The process...
First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on therapies that deliver extracellular vesicles released by stem cells rather than the...
