September 3, 2024. by Krishna Ramanujan, Cornell University Microcarrier-microbioreactor setup and protocol. Credit: Journal of Translational Medicine (2024). DOI: 10.1186/s12967-024-05373-7A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and damage after heart attacks, countering transplant rejection and...
Tag: <span>cell therapy</span>
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FDA approves engineered cell therapy for treating rare sarcoma
August 5, 2024 by Julie Grisham, Memorial Sloan Kettering Cancer Center Credit: CC0 Public DomainThe U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called synovial sarcoma. Afami-cel is the first engineered T...
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Novel CAR T therapy and shorter targeted therapy durations show promise for patients with leukemia
MAY 31, 2024 by University of Texas M. D. Anderson Cancer Center Credit: Unsplash/CC0 Public Domain Researchers from The University of Texas MD Anderson Cancer Center presented positive clinical results from two studies today at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. The findings highlight strong remission and response rates and offer...
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A new natural killer cell therapy product with promising anticancer effects
by DGIST (Daegu Gyeongbuk Institute of Science and Technology) Schematic diagram of the MBP technology in NK cells and expected role in the tumor site. (A) Schematic illustration of cytokine engineered MBP NK cells and functional difference between parental NK-92 cells and MBP NK cells. Because of self-stimulation via MBP IL-2, MBP NK cells can...
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New injectable cell therapy could resolve osteoarthritis
by Atrium Health Wake Forest Baptist Credit: CC0 Public Domain Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created a promising injectable cell therapy to treat osteoarthritis that both reduces inflammation and also regenerates articular cartilage. Recently identified by the Food and Drug Administration as a public health crisis, osteoarthritis affects more than 520...
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Research team delivers a new first in heart failure treatment using cell therapy
by Texas Heart Institute Physician-scientists at The Texas Heart Institute announced today the results of the largest cell therapy trial in patients with heart failure to date. The therapy benefited patients by reducing the risk of heart attack and stroke and improving the heart’s ejection fraction, especially in patients who have high levels of inflammation....
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Cell therapy may slow kidney damage from type 2 diabetes
by National University of Ireland, Galway Credit: Pixabay/CC0 Public Domain University of Galway, in collaboration with the NEPHSTROM Consortium, has announced promising results from a new cell therapy trial for people living with diabetes. The NEPHSTROM clinical trial is taking the first steps to investigate the value of a novel cell therapy for adults who...
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Cell therapy improves progression-free survival in advanced melanoma, first phase 3 study shows
by European Society for Medical Oncology Lead author Professor John Haanen. Credit: European Society for Medical Oncology A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial. “This study...
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Simple blood test predicts neurotoxic complications of CAR-T cell therapy
by Washington University School of Medicine A new study from Washington University School of Medicine in St. Louis suggests a simple blood test—administered before CAR-T cell treatment is initiated—may identify which patients are predisposed to developing neurotoxic side effects after CAR-T cell therapy. Severe side effects can include seizures, brain swelling and strokes. Evidence of a...
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Cell therapy for lung disease? Proof-of-concept study shows promise
by Nancy Fliesler, Children’s Hospital Boston Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110662 Many serious pulmonary diseases, including genetic lung diseases, lack an effective treatment other than the most extreme: lung transplant. A team at Boston Children’s Hospital envisions a much better option: cell therapy, using lung stem cells created from patients’ own cells to repair...