Penn study demonstrates that engineered macrophages, which can be targeted to tumors, may be a possible new immune-based treatment of some cancers. Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which...
Tag: <span>cell therapy</span>
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Placental cell therapy could deliver new treatment options for liver disease
by Monash University Credit: CC0 Public Domain A cell therapy could reduce inflammatory response in liver disease, offering hope to thousands of Australians suffering from the disease. Inflammation underpins hundreds of health conditions, contributing to more than 50 percent of deaths worldwide, and Hudson Institute has Australia’s largest team of inflammation researchers, whose sole focus is...
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Researchers working on injection-free cell therapy for diabetes
In a person with type 1 diabetes, the body mistakenly attacks pancreatic cells that produce insulin, a hormone responsible for regulating blood sugar. Without insulin, serious and eventually fatal symptoms will occur. Yet, imagine if, instead of needing daily insulin injections, people with diabetes could have insulin-producing cells placed back into the body, fixing the problem...
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Scientists make strides toward an ‘off-the-shelf’ immune cell therapy for cancer
by Tiare Dunlap, University of California, Los Angeles An engineered HSC-iNKT cell (blue) attacking a human tumor cell. Credit: Yang lab/UCLA Immunotherapies, which harness the body’s natural defenses to combat disease, have revolutionized the treatment of aggressive and deadly cancers. But often, these therapies—especially those based on immune cells—must be tailored to the individual patient,...
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Study uncovers a new understanding of how mesenchymal stromal cells benefit patients in cell therapy
by Monash University Apoptotic MSC (red) is engulfed by a macrophage (green). Credit: Professor Tracy Heng The therapeutic benefit to patients receiving mesenchymal stromal cell (MSC) therapy is not because the injected cells remain viable, but because of cell death, researchers at the Monash Biomedicine Discovery Institute (BDI) have found. In recent years, significant efforts...
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After Setbacks, Cell Therapy for Glioblastoma Moves onto New Chapter
Donald M. O’Rourke, MD, director of the Glioblastoma Translational Center of Excellence at Penn Medicine, feels energized. After a lot of frustration and too few successes, the cell therapy field has reached a new phase in its pursuit for better treatments for the deadly brain cancer glioblastoma multiforme (GBM). For decades, treatment approaches using surgery,...
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Mid-term clinical trial results show similar outcomes in promising cell therapies for CLI
ALPHAMED PRESS IMAGE: THE TWO THERAPIES DEMONSTRATED SIMILAR MID-TERM SAFETY AND EFFICACY, WHILE EACH CELL THERAPY HAD ITS UNIQUE ADVANTAGES AND ARE RECOMMENDED FOR CERTAIN CONDITIONS: FOR EXAMPLE, PBMNCS FOR PATIENTS WITH 2 OR MORE CRITICAL ISCHEMIC LIMBS AND PCC’S FOR PATIENTS WITH SIGNIFICANT PAIN. CREDIT: ALPHAMED PRESS Durham, NC – Mid-term results of the...
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Liposuction treatment hope for coronavirus: Stem cells taken from fat-reduction donors boosts survival rates FIVE-fold for critically-ill patients hooked up to ventilators
Of a small number of patients, 15% died compared with the 85% expected Overall 70% of patients who were on the brink of death saw improvements The researchers admitted they did not expect such positive results The treatment works by injecting patients with cells taken from fat tissue The stem cells are known to bolster...
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Liposuction treatment hope for coronavirus: Stem cells taken from fat-reduction donors boosts survival rates FIVE-fold for critically-ill patients hooked up to ventilators
By VANESSA CHALMERS HEALTH REPORTER FOR MAILONLINE PUBLISHED: 13:41 EDT, 10 July 2020 | UPDATED: 13:54 EDT, 10 July 2020 Of a small number of patients, 15% died compared with the 85% expected Overall 70% of patients who were on the brink of death saw improvements The researchers admitted they did not expect such positive...
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Silicones may lead to cell death
by Radboud University Nijmegen Silicone molecules from breast implants can initiate processes in human cells that lead to cell death. Researchers from Radboud University have demonstrated this in a new study published on 12 June in Scientific Reports. “However, there are still many questions about what this could mean for the health effects of silicone...