by Nancy Fliesler, Children’s Hospital Boston Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110662 Many serious pulmonary diseases, including genetic lung diseases, lack an effective treatment other than the most extreme: lung transplant. A team at Boston Children’s Hospital envisions a much better option: cell therapy, using lung stem cells created from patients’ own cells to repair...
by Julia Evangelou Strait, Washington University School of Medicine A study by researchers at Washington University School of Medicine in St. Louis shows that treatment with an immunity boosting protein called interleukin 7 (IL-7) after an infusion of genetically modified T cells causes the cancer-fighting CAR-T cells to grow in number and become more effective at...
by Northwestern University Mice treated with novel approach to cell therapy saw dramatic shrinkage in tumors compared to those treated with traditional cell therapy approaches. Credit: Please credit Shana Kelley Lab / Northwestern University Northwestern University scientists have developed a new tool to harness immune cells from tumors to fight cancer rapidly and effectively. Their...
Penn study demonstrates that engineered macrophages, which can be targeted to tumors, may be a possible new immune-based treatment of some cancers. Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which...
by Monash University Credit: CC0 Public Domain A cell therapy could reduce inflammatory response in liver disease, offering hope to thousands of Australians suffering from the disease. Inflammation underpins hundreds of health conditions, contributing to more than 50 percent of deaths worldwide, and Hudson Institute has Australia’s largest team of inflammation researchers, whose sole focus is...
In a person with type 1 diabetes, the body mistakenly attacks pancreatic cells that produce insulin, a hormone responsible for regulating blood sugar. Without insulin, serious and eventually fatal symptoms will occur. Yet, imagine if, instead of needing daily insulin injections, people with diabetes could have insulin-producing cells placed back into the body, fixing the problem...
by Tiare Dunlap, University of California, Los Angeles An engineered HSC-iNKT cell (blue) attacking a human tumor cell. Credit: Yang lab/UCLA Immunotherapies, which harness the body’s natural defenses to combat disease, have revolutionized the treatment of aggressive and deadly cancers. But often, these therapies—especially those based on immune cells—must be tailored to the individual patient,...
by Monash University Apoptotic MSC (red) is engulfed by a macrophage (green). Credit: Professor Tracy Heng The therapeutic benefit to patients receiving mesenchymal stromal cell (MSC) therapy is not because the injected cells remain viable, but because of cell death, researchers at the Monash Biomedicine Discovery Institute (BDI) have found. In recent years, significant efforts...
Donald M. O’Rourke, MD, director of the Glioblastoma Translational Center of Excellence at Penn Medicine, feels energized. After a lot of frustration and too few successes, the cell therapy field has reached a new phase in its pursuit for better treatments for the deadly brain cancer glioblastoma multiforme (GBM). For decades, treatment approaches using surgery,...
ALPHAMED PRESS IMAGE: THE TWO THERAPIES DEMONSTRATED SIMILAR MID-TERM SAFETY AND EFFICACY, WHILE EACH CELL THERAPY HAD ITS UNIQUE ADVANTAGES AND ARE RECOMMENDED FOR CERTAIN CONDITIONS: FOR EXAMPLE, PBMNCS FOR PATIENTS WITH 2 OR MORE CRITICAL ISCHEMIC LIMBS AND PCC’S FOR PATIENTS WITH SIGNIFICANT PAIN. CREDIT: ALPHAMED PRESS Durham, NC – Mid-term results of the...
