September 11, 2024 by University of California, Los Angeles Credit: Pixabay/CC0 Public DomainResearchers have for the first time identified degeneration-associated “molecular markers”—observable changes in cells and their gene-regulating networks—that are shared by several forms of dementia that affect different regions of the brain. Critically, the UCLA-led research, published in the journal Cell, also identified markers...
by Melissa Rohman, Northwestern University Immunostaining of protein constituents of the cell-cell adhesive junction in the desmosome in skin biopsies taken from a patient with SAM syndrome harboring a genetic mutation in Dsg1. The levels of Dsg1 and its associated partner protein plakoglobin (PG) are restored at cell borders following ustekinumab treatment. Credit: Northwestern University...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE Mount Sinai researchers have identified genetic and cellular mechanisms of Crohn’s disease, providing new insights for future treatments that could offer a tailored approach to patients with the chronic inflammatory disease, according to a study published in Nature on March 31. The researchers found that blocking the common cytokine receptor subunit...
