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Improved cellular recycling could benefit patients with neurodegenerative conditions
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Improved cellular recycling could benefit patients with neurodegenerative conditions

Peer-Reviewed Publication THE HOSPITAL FOR SICK CHILDREN NON-FUNCTIONING PARTS OF THE CELL LIKE DAMAGED PEROXISOMES (PICTURED IN YELLOW) ARE NOT RECYCLED PROPERLY. ON THE RIGHT IS AN IMAGE FROM THE KIM-BANDSMA LAB SHOWING CELLS WITH DISRUPTED RECYCLING, AND ON THE LEFT IS A CELL WITH FUNCTIONING RECYCLING. CREDIT: THE HOSPITAL FOR SICK CHILDREN (SICKKIDS). For...

Scientists discover a rare neurological disease involving cellular recycling
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Scientists discover a rare neurological disease involving cellular recycling

by Anna Rogers, NIH/National Human Genome Research Institute Bi-allelic variants in ATG4D segregate with a neurodevelopmental disorder in three individuals from two unrelated families. a Neuroimaging of Individual 1 showing mild cerebellar atrophy disproportionately involving the superior cerebellar hemispheres and vermis at 5 years 3 months (arrowhead in T2-weighted sagittal view image, left panel). There...