by Impact Journals LLC Summary schematic of MET+LEU effects during SD in muscle cells. Credit: 2023 Petrocelli et al. Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, researchers found that...
Tag: <span>cellular senescence</span>
Post
Cellular senescence plays a significant role in cerebral tumors
by Marie Simon, Paris Brain Institute Cells derived from a murine glioblastoma model and embedded in a 3D extracellular matrix. Confocal microscope. Credit: Isabelle Le Roux. Glioblastomas are the most common malignant tumors of the adult brain. They resist conventional treatment, including surgery, followed by radiation therapy and chemotherapy. Despite this armamentarium, glioblastomas inexorably recur....
Post
Targeting Cellular Senescence as a Basis for Treating Osteoporosis
Senescent cells accumulate with age, causing tissue dysfunction throughout the body via their inflammatory secretions. One of those dysfunctions is the age-related imbalance in bone remodeling, favoring the osteoclasts that break down bone tissue at the expense of the osteoblasts that rebuild it. The result is osteoporosis, the characteristic loss of bone mass and resilience that...
Post
Imflammasome Induced Cellular Senescence
Researchers here show that signaling related to inflammatory regulation within a cell, undertaken in response to stress, can induce cellular senescence. Preventing the onset of the senescent state in response to some forms of stress may be beneficial, and indeed may be a part of the way in which therapies such as low dose mTOR...
Post
NANOG Expression versus Cellular Senescence
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living animals, but very few are actually reprogramming senescent cells into normal cells. It isn’t clear that this reversal of the senescent state is a good idea,...
Post
Aging: Cdkn1a transcript variant 2 is a marker of aging and cellular senescence
IMPACT JOURNALS LLC IMAGE: The Cdkn1a variant 2 transcript is preferentially induced during aging. (A) We designed primers (black arrows) to specifically detect Cdkn1a variant 1 and 2 transcripts, spanning the first and second exons in each case. The protein-coding region is indicated as well as the ATG start codon (brown arrow). Transcription starts at...