by Nagoya University Under normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functional machinery is impaired, the splicing ratio of MAPT exon 10+/exon 10- is increased, which in turn results in an increased 4R-Tau/3R-Tau ratio. The findings...
by Katherine Fenz, Rockefeller University Epidermal stem cells (green) form small bud-shaped structures that later become tumors. Credit: Laboratory of Cell Biology and Development at The Rockefeller University All cancers are the result of cells that have gone haywire, multiplying out of control and expanding beyond their normal constraints. But not all tumors are the...
Synthetic compound could serve as prototype for a novel class of drugs to treat neurological damage DZNE – GERMAN CENTER FOR NEURODEGENERATIVE DISEASES Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan have developed a neurologically acting protein and tested it in laboratory studies. In mice, the experimental compound ameliorated symptoms of...
by German Center for Neurodegenerative Diseases CPTX (orange) combines functional domains present in natural synaptic organizing proteins in a unique way. The compound was designed to act as a universal bridge builder for excitatory connections between nerve cells. Credit: DZNE / Alexander Dityatev Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan...
Conducting genetic screening in hundreds of autopsied brain samples, investigators identified shared molecular mechanisms in Alzheimer’s disease and LATE, a common brain disorder BRIGHAM AND WOMEN’S HOSPITAL Alzheimer’s disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the...
by Case Western Reserve University Luis Ortiz-Rodríguez grew up on the beaches of Puerto Rico—surfing, swimming and running in the hot sand—and swears he had never put on sunblock a day in his life. Then the day came when he peered through an ultrafast laser spectrometer at the College of Arts & Sciences at Case...
by Chinese Academy of Sciences Gastric cancer is the third leading cause of cancer death worldwide, accounting for over 1,000,000 new cases and nearly 800,000 deaths per year. The poor prognosis of gastric cancer is largely due to the difficulty in early diagnosis of peritoneal metastasis. Separation and characterization of cancer cells are essential for...
Report: How a protein protects cells from death UNIVERSITY OF HOUSTON RAJ KUMAR, CLINICAL PROFESSOR OF BIOCHEMISTRY, UNIVERSITY OF HOUSTON COLLEGE OF MEDICINE, FOUND A MECHANISM FOR HOW THE PROTEIN, CALLED NUCLEAR FACTOR OF ACTIVATED T CELLS 5 (NFAT 5), WORKS… view more CREDIT: UNIVERSITY OF HOUSTON A University of Houston College of Medicine researcher...
Toward an era where aging can be controlled KUMAMOTO UNIVERSITY THE HUMAN BODY AND THE CELLS THAT MAKE IT UP HAVE A “PROGRAM ” FOR AGING. IT IS THOUGHT THAT THERE IS AN ACCUMULATION OF SENESCENT CELLS IN TISSUES AND ORGANS… view more CREDIT: PROFESSOR MITSUYOSHI NAKAO Researchers from Kumamoto University in Japan have used...
by Jeremy Thomas, Lawrence Livermore National Laboratory Laboratory team cultured rodent-derived neurons on microelectrode arrays and allowed the cultures to form networks, supplementing them with astrocytes and oligodendrocytes — cell types that play a critical role in neuronal health and function. Pictured is an immunofluorescence image of a complex culture, showing neurons (stained red), astrocytes...
