UNIVERSITY OF HELSINKI Researchers have uncovered sphingolipid accumulation as a new mechanism that affects ageing. Ceramides, the best-known class of sphingolipids, accumulate in aged muscle, impairing its function while also affecting functional capacity in older adults. These findings encourage researchers to develop potential pharmaceutical agents. A study carried out at the University of Helsinki and...
Tag: <span>ceramides</span>
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Ceramides found to be key in aging muscle health
by Ecole Polytechnique Federale de Lausanne Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domain During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides....
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Review argues for therapeutics to treat cholesterol cousins called ceramides
by Cell Press Credit: CC0 Public Domain Therapeutics that target lipids called ceramides might hold potential for treating cardiometabolic disease, argues a review article published November 5th in the journal Trends in Pharmacological Sciences. The authors summarize evidence supporting a strong relationship between ceramides and a range of diseases in animals and humans and compare...