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The chemical imbalance theory of depression is dead, but that doesn’t mean antidepressants don’t work
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The chemical imbalance theory of depression is dead, but that doesn’t mean antidepressants don’t work

by Christopher Davey, The Conversation Credit: Shutterstock The chemical imbalance theory of depression is well and truly dead. A paper by Joanna Moncrieff and colleagues, long-time critics of the effectiveness of antidepressants, has caused a splash. The paper provides a summary of other summaries that confirm there is no evidence to support the idea that...

Depression is probably not caused by a chemical imbalance in the brain, says new study
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Depression is probably not caused by a chemical imbalance in the brain, says new study

by Joanna Moncrieff and Mark Horowitz, The Conversation Credit: TanyaJoy/Shutterstock For three decades, people have been deluged with information suggesting that depression is caused by a “chemical imbalance” in the brain—namely an imbalance of a brain chemical called serotonin. However, our latest research review shows that the evidence does not support it. Although first proposed in the 1960s,...