ROCKEFELLER UNIVERSITY PRESS IMAGE: COMPARED WITH A NORMAL CELL (LEFT), AN OLIGODENDROCYTE LACKING TDP-43 (CENTER) PRODUCES LESS MYELIN (GREEN) BECAUSE IT IS UNABLE TO SYNTHESIZE OR TAKE UP SUFFICIENT AMOUNTS OF CHOLESTEROL. SUPPLEMENTING TDP-43–DEFICIENT CELLS WITH CHOLESTEROL (RIGHT) RESTORES MYELIN PRODUCTION. CREDIT: ©2021 HO ET AL. ORIGINALLY PUBLISHED IN <EM>JOURNAL OF CELL BIOLOGY</EM>. Researchers in Singapore...