by Impact Journals LLC Experimental design for the results shown in Figures 3 and 4. Credit: 2023 Copp et al. A new research paper titled “Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes” has been published in Aging. While advanced age is widely recognized as the greatest risk...
by Anne M Stark, Lawrence Livermore National Laboratory Gene expression in mouse knee joint chondrocytes was analyzed using single-cell RNA sequencing, which identified nine chondrocyte subpopulations with distinct molecular profiles. Credit: Lawrence Livermore National Laboratory Articular cartilage is a connective tissue lining the surfaces of joints. When the cartilage severely wears down, it leads to osteoarthritis...
Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11. The study is the first, say its authors, to provide evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role—keeping on hand...
