Autologous chondrocyte implantation (ACI) is a two-step surgical procedure to restore cartilage around a joint and treat cartilage defects. Cartilage is the connective tissue found throughout the body that protects joints and bones. Cartilage consists of cells called chondrocytes. “Autologous” means the transplant only involves cells or tissues from a person’s own body rather than...
Tag: <span>Chondrocytes</span>
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Sirtuin 6 activation rescues the age-related decline in DNA damage repair in chondrocytes: Study
by Impact Journals LLC Experimental design for the results shown in Figures 3 and 4. Credit: 2023 Copp et al. A new research paper titled “Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes” has been published in Aging. While advanced age is widely recognized as the greatest risk...
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New research identifies injury-induced molecular changes in chondrocytes, at single-cell level
by Anne M Stark, Lawrence Livermore National Laboratory Gene expression in mouse knee joint chondrocytes was analyzed using single-cell RNA sequencing, which identified nine chondrocyte subpopulations with distinct molecular profiles. Credit: Lawrence Livermore National Laboratory Articular cartilage is a connective tissue lining the surfaces of joints. When the cartilage severely wears down, it leads to osteoarthritis...
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Rodents with trouble walking reveal potential treatment approach for most common joint disease
Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11. The study is the first, say its authors, to provide evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role—keeping on hand...