by Wayne State University Schematic presentation of the pathways leading to acute and chronic inflammation and unalamation. Credit: Frontiers in Immunology (2024). DOI: 10.3389/fimmu.2024.1460302 A recently published study led by Wayne State University on a new approach to understanding chronic inflammation could lead to new advancements in the treatment of many debilitating medical conditions, including cancer. The study,...
Tag: <span>chronic inflammation</span>
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Researchers discover how chronic inflammation worsens heart failure
by Sarah C. P. Williams, Gladstone Institutes Stress-activated Cx3cr1+ macrophages contribute to heart failure pathogenesis. Credit: Nature (2024). DOI: 10.1038/s41586-024-08085-6 If you cut your arm or undergo surgery, scarring can be a good thing; the scar tissue produced by cells called fibroblasts helps you heal. In most organs of the body, however, the accumulation of scarring (called fibrosis) is...
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Chronic inflammation and inactivity may affect age-related changes in gene and protein expression in skeletal muscle
by Wiley Credit: CC0 Public DomainNew research indicates that some age-related changes in gene and protein expression in the skeletal muscles of older individuals may be affected more by physical inactivity and chronic inflammation than primary aging, or intrinsic maturational processes. Physical inactivity and chronic inflammation are the most important drivers of secondary aging, or changes...
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Study provides insights into role of ‘hunger hormone’ receptor in obesity-related chronic inflammation
by Laura Muntean, Texas A&M University Credit: Molecular Metabolism (2023). DOI: 10.1016/j.molmet.2023.101852A team comprised primarily of Texas A&M AgriLife Research scientists has made an important discovery that could lead to a novel treatment for obesity and obesity-associated diseases or conditions. Details of the discovery can be found in the study “Nutrient-sensing growth hormone secretagogue receptor in...
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Researchers discover COVID-19 does not infect immune cells that contribute to chronic inflammation
by University of Queensland Credit: Pixabay/CC0 Public Domain A treatment to prevent runaway inflammation in patients with severe COVID-19 is a step closer after a University of Queensland-led study into how immune cells respond to the virus. Dr. Larisa Labzin and Professor Kate Schroder from UQ’s Institute for Molecular Bioscience with Dr. Sarah Londrigan at the...
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Multiple sclerosis discovery could end disease’s chronic inflammation
by Josh Barney, University of Virginia Separately housed Cd4creAhrfl/fl recover from EAE with increased myelin staining at chronic phase. (A) Clinical score of Cd4creAhrfl/fl and Ahrfl/fl mice cohoused (females; representative plot includes n = 9 mice/group; total replicates of N = 2 experiments). Spinal cords sections of Cd4creAhrfl/fl and Ahrfl/fl were stained with Luxol fast blue and hematoxylin/eosin stain at day...
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Enzyme “sugar tag” blocks excess cell death behind chronic inflammation
By Nick Lavars May 16, 2022 A new discovery around excessive cell death in the body offers new hope of treating conditions driven by chronic inflammation Depositphotos Uncontrolled inflammation in the human body can drive a variety of serious health conditions, including cancer and rheumatoid arthritis, so discoveries around how it works can benefit the...
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Recurrent UTIs linked to gut microbiome, chronic inflammation
by Tamara Bhandari, Washington University School of Medicine in St. Louis Study design and sample collection for the UMB study. Credit: Nature Microbiology (2022). DOI: 10.1038/s41564-022-01107-x One of the greatest frustrations regarding urinary tract infections (UTIs) is that they so often recur. UTIs are caused by bacteria in the urinary tract and characterized by frequent and painful...
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Alpaca nanobodies target and dissolve root cause of chronic inflammation
By Nick Lavars April 19, 2022 Alpaca immune systems have some properties that may be very useful to medical science Depositphotos By tapping into the unique immune system of alpacas, scientists have developed a promising technique for tempering chronic inflammation associated with conditions such as arthritis. The breakthrough hinges on what are known as nanobodies,...
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A new approach against chronic inflammation
by University of Bonn ASC specks shown here in different colors are large complexes of many copies of the ASC protein. They can cause immense damage in the tissue. Credit: Franklin Lab / University of Bonn The cells in our body have a sophisticated alarm system, the inflammasome. Its central component is the so-called ASC...