Peer-Reviewed Publication Mass General Brigham FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that patrols our body, ever vigilant for signs of infection or injury. Now, over 100 years after the...
Tag: <span>chronic inflammatory disease</span>
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Chronic-inflammatory liver disease therapy with synthetic bile acid also directly affects the immune system
by Medical University of Vienna Chronic-inflammatory liver disease: Therapy with synthetic bile acid also directly affects the immune system. Credit: Nerthuz/Shutterstock Primary sclerosing cholangitis (PSC) is a rare, chronic inflammatory disease of the bile ducts and difficult to treat. Studies conducted by the Division of Gastroenterology and Hepatology at MedUni Wien under the guidance of Michael...
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Personalised treatment of chronic inflammatory diseases did not produce a better effect
by Julie Nybakk Kvaal, University of Oslo From left to right: Guro L. Goll, consultant physician and postdoc, Silje W. Syversen, consultant physician and postdoc, Kristin K. Jørgensen, consultant physician and postdoc at Ahus and Espen A. Haavardsholm, professor at Institute of Clinical Medicine and Head of research and innovation at Diakonhjemmet hospital. Credit: Nicolas Tourrenc It is not...
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Scientists ID two molecules that inhibit proteins involved in chronic inflammatory disease
Representative conformations of T23 in TNF and RANKL. Scientists have identified two small molecules that could be pursued as potential treatments for chronic inflammatory diseases. According to a paper published in PLOS Computational Biology, the researchers singled out the molecules using a new drug screening approach they developed. Both molecules, known as T23 and T8, inhibit...