ALPHAMED PRESS IMAGE: BIOLOGICAL AGING OF TRACHEOBRONCHIAL TISSUE SPECIFIC STEM CELLS (TSC) AND THEIR TROPHIC UNIT, THE PSEUDOSTRATIFIED CONDUCTING AIRWAY EPITHELIUM. EACH INJURY ACTIVATES A SUBSET OF TSC WHICH PROLIFERATE AND UNDERGO TERMINAL DIFFERENTIATION. THUS, EACH INJURY CYCLE DEPLETES THE TSC POOL AND MANY INJURIES COMPROMISE EPITHELIAL REGENERATION. OVER TIME, BIOLOGICAL AGE EXCEEDS CHRONOLOGICAL AGE...
by The Translational Genomics Research Institute Credit: CC0 Public Domain The results of a study by an international scientific team co-led by the Translational Genomics Research Institute (TGen), an affiliate of the City of Hope, suggest that—like pouring water atop a wellhead before pumping—the airway cells of patients with chronic lung diseases are “primed” for infection by the...
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IMAGE: Shown is a transmission electron microscope image of exosomes purified from fluid from the lungs of a patient with COPD. A new study from Washington University School of Medicine in St. Louis has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for...
NIH/NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES IMAGE: THE RESEARCH SHOWS THAT INHALING HYALURONAN INTERFERES AT ALMOST EVERY STEP OF THE COPD CYCLE, MAKING IT A POTENT TREATMENT FOR CHRONIC LUNG DISEASE. CREDIT: STAVROS GARANTZIOTIS, M.D. Researchers at the National Institutes of Health and their collaborators found that inhaling unfragmented hyaluronan improves lung function in patients suffering...
by Adam Pope, University of Alabama at Birmingham New research from scientists at the University of Alabama at Birmingham published in the New England Journal of Medicine has found that beta-blockers used in a clinical trial for patients with chronic obstructive pulmonary disease do not reduce the risk of flare-ups of the disease, also called...
Patients with some of the most common lung diseases are substantially more likely to suffer a heart attack and develop other major heart problems according to new research. The team of heart and lung doctors from the University of Manchester and Aston Medical School found people with asthma, chronic obstructive pulmonary disease (COPD) and lung fibrosis, were more likely to develop, and die from, heart disease and heart failure. The study of nearly 100,000 people with lung disease in...
Discovery holds promise for developing urgently needed new therapies in COPD MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Chronic obstructive pulmonary disease (COPD), an inflammatory disease of the small airways in the lungs, affects 16 million Americans and is the fourth leading cause of death in the United States, according to the National Heart Lung and Blood Institute (NHLBI). Identifying small airway disease in its earliest stages, when it...
As a cold end, a severe mucus cough starts. Sound familiar? Two studies now give explanations: First, crucial mechanisms of the mucus in both diseased and healthy airways; second, what happens in such chronic lung diseases as cystic fibrosis and chronic obstructive pulmonary disease (COPD). IMAGE: THIS IS GUNNAR C. HANSSON, PROFESSOR OF MEDICAL BIOCHEMISTRY AT SAHLGRENSKA ACADEMY, UNIVERSITY OF GOTHENBURG. CREDIT: JOHAN WINGBORG “This is new knowledge, but there are...
