September 13, 2024 by Karolinska Institutet Long-read RNA-sequencing validates the predicted alternative transcripts related to the ncBAF complex in SF3B1-mutated CLL. Credit: Leukemia (2024). DOI: 10.1038/s41375-024-02379-4RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript abundances. One area of increasing interest is alternative splicing, a process that allows...
by Dana-Farber Cancer Institute Credit: Pixabay/CC0 Public Domain Every year, up to 1% of patients with chronic lymphocytic leukemia (CLL), a slow-growing blood cancer, have their disease transform into a far more aggressive cancer, a form of lymphoma known as Richter’s syndrome. For the most part, the genomic changes that underlie this metamorphosis and push...
by Dana-Farber Cancer Institute New research shows that genetics account for only five to 10 per cent of risk for most human diseases, and that gene testing is a poor predictor of whether someone will develop diseases including diabetes, Alzheimer’s and many types of cancer. Credit: CC0 Public Domain A three-drug combination that sent chronic...
