WOLTERS KLUWER HEALTH March 4, 2022 – Women who were younger at the time of their first menstrual period (menarche) are more likely to report chronic pain in adulthood, reports a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published in the Lippincott portfolio by Wolters Kluwer. “[W]e found strong associations...
Tag: <span>chronic pain</span>
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On a mission to alleviate chronic pain
About 50 million Americans suffer from chronic pain, which interferes with their daily life, social interactions, and ability to work. MIT Professor Fan Wang wants to develop new ways to help relieve that pain, by studying and potentially modifying the brain’s own pain control mechanisms. Her recent work has identified an “off switch” for pain,...
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New life for a cancer drug that reprograms pain pathways to treat chronic pain
IMAGE: UPPER RIGHT: SCREENING COMPOUNDS IN THE “JUNKYARD OF CANCER DRUGS”, AKIN TO SIEVING THROUGH SAND, LOOKING FOR GOLD NUGGETS. KENPAULLONE WAS IDENTIFIED AS A PROMISING CANDIDATE OWING TO ITS ABILITY TO SWITCH ON THE KCC2 GENE, WHICH HAS BEEN PREDICTED TO ALLEVIATE CHRONIC PAIN. UPPER LEFT: INTRACTABLE CHRONIC PAIN IS A SERIOUS AND PRESSING...
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Study first to reveal specific molecular mechanism that controls the transition from acute to chronic pain
by University of California, Irvine “This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain,” said Daniele Piomelli, Ph.D., Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology....
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Emotional aspects of chronic pain isolated in brain circuitry
Negative emotional states and physical pain are intimately connected. Numerous people who suffer from chronic, persistent pain also deal with negative emotions and loss of motivation. Some even become clinically depressed eventually, and doctors sometimes prescribe antidepressants to treat chronic pain, even though the pathways that link pain and mood are poorly understood. Now, studying...
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Chronic pain treatment should include psychological interventions, says research
by Association for Psychological Science Credit: CC0 Public Domain Pain is the body’s way of alerting the brain to injury and disease. Without a robust pain response, physical trauma could go unnoticed and untreated. Some people, however, experience chronic pain that lasts long after an injury has healed or has no easily identifiable cause. Unfortunately, treating...
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Long-lasting pain relief without opioids: Researchers develop a novel, local treatment for chronic pain
by University at Buffalo Credit: Unsplash/CC0 Public Domain An investigation into the origins of the sensation of pain has led to the development of a novel and durable treatment for inflammatory pain that could be a promising alternative to opioids. The preclinical research was conducted by neuroscientists and pharmacologists, all in the Jacobs School of Medicine...
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Novel neural stimulation protocol for treating chronic pain
by Anna Zarra Aldrich, University of Connecticut Credit: Pixabay/CC0 Public Domain Any pain you experience is all in your head—really. When we feel pain in response to a stimulus, whether stubbing a toe, burning a finger, or something more severe, the feeling of pain is the result of a complex signaling pathway in the nervous system....
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New approach effectively relieves chronic low back pain
Anyone with an aching back knows just how debilitating that pain can be. Now, Stanford Medicine researchers may have good news for the 500 million people worldwide experiencing low back pain. Stanford pain psychologist Beth Darnall, PhD, has developed a single-session, two-hour class called Empowered Relief, which aims to rapidly equip patients with pain management skills. The first...
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‘Where does it hurt?’ predicts chronic pain outcomes, study shows
by Public Library of Science Heatmap with body map region on the horizontal axis and each row on the vertical axis representing an individual patient out of the entire cohort (N = 21,658 unique patients) organized by cluster membership. Credit: Alter et al, 2021, PLOS ONE (CC-BY 4.0, creativecommons.org/licenses/by/4.0/) Pain distribution is reported on a body map, on...