VALL D’HEBRON INSTITUTE OF ONCOLOGY Preliminary results from a phase I clinical trial show that the first in class MYC inhibitor Omomyc (OMO-103) has few side effects, is tolerable, and stabilizes disease in some patients. Developed in-house by Laura Soucek’s Models of Cancer Therapies Group and VHIO-ICREA spin-off Peptomyc SL, OMO-103 targets the MYC oncogene...
Tag: <span>Clinical trial</span>
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Two popular diabetes drugs outperform others in large clinical trial
by National Institute of Diabetes and Digestive and Kidney Diseases Credit: Pixabay/CC0 Public Domain In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications approved by the U.S. Food and Drug Administration to maintain blood...
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Lupus Pill Shows Promise in Mice; Clinical Trial Underway
Summary: Afimetoran, a newly developed pill to treat lupus, not only prevents lupus-like symptoms in mice, it also reverses signs of organ damage caused by the disease and prevents death. The medication is now undergoing phase 2 clinical trials to assess its effectiveness in lupus patients. Source: American Chemical Society Lupus is an autoimmune disease that attacks...
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Clinical trial suggests Parkinson’s drug is safe in humans
by Bob Yirka, Medical Xpress Reducing the activity of the enzyme LRRK2 in the human brain with DNL201 may help protect cells in the midbrain and treat Parkinson’s disease. Credit: P. Lewis, et al. A large team of researchers from Denali Therapeutics, working with colleagues from multiple entities in the U.S. and one in Canada,...
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‘First time this has happened’: Doctors left shocked after clinical trial for cancer drug cures the disease in EVERY participant
By MANSUR SHAHEEN U.S. DEPUTY HEALTH EDITOR FOR DAILYMAIL.COM PUBLISHED: 16:59 EDT, 6 June 2022 | UPDATED: 18:07 EDT, 6 June 2022 A new colorectal cancer drug has shocked researchers with how effective it is against the highly dangerous disease, as it virtually cured it in every member of a clinical trial. Dostarlimab, a monoclonal antibody drug, smashed expectations in...
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What is an Open-Label Clinical Trial?
By Reginald Davey Reviewed by Emily Henderson, B.Sc. Clinical trials are a central part of the drug and medical intervention development process. Different trial designs can be used by clinical researchers, with open-label trials one such design. This article will discuss what open-label trials are. Image Credit: PopTika/Shutterstock.com The Importance of Clinical Trials and Good Trial...
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TGen, HonorHealth and Irish biomedical firm initiate promising ‘Nieto’ clinical trial against pancreatic cancer
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE SCOTTSDALE, Ariz. — March 18, 2022 — The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, in association with HonorHealth Research and Innovation Institute and Systems Biology Ireland (SBI), have begun a clinical trial, testing the combination of two drugs against advanced pancreatic cancer, one of the most deadly and difficult-to-treat malignancies. The...
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NIH launches clinical trial of three mRNA HIV vaccines
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines. NIAID is sponsoring the study, called HVTN 302, and the NIAID-funded HIV Vaccine...
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New technology leads successful clinical trial to treat dry eye disease
by Texas Tech University A team led by Hironmoy Das, Ph.D., from the TTUHSC Jerry H. Hodge School of Pharmacy recently completed a clinical trial using corneal epithelial stem cells to improve outcomes for DED patients. Credit: TTUHSC Several studies conducted over the last decade have concluded that dry eye disease (DED) affects up to 50%...
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Researchers find gaps in clinical trial data sharing
by Mike Cummings, Yale University Credit: CC0 Public Domain Access to clinical-trial data helps doctors make informed prescribing decisions and promotes good science, but a new study co-authored by Yale researchers reveals that few pharmaceutical companies are fully transparent about the data behind the products they develop. The study also shows that large companies are far more transparent...