by American Association for Cancer Research Credit: Unsplash/CC0 Public Domain Researchers identified a higher rate of clonal hematopoiesis (CH) and prevalence of treatment-induced STAT3 gene mutations in blood samples from a large cohort of survivors of pediatric cancer, compared with age-matched controls. The study is published in Cancer Discovery. Pediatric cancers are often treated with aggressive chemotherapy...
A major challenge in the study of aging and age-related disease is establishing the direction of causation. A great many mechanisms of aging are known, but it is difficult to firmly establish the relationships between them. The body is made up of many interacting systems, and changes in any one system tend affect the others, directly or...
MASSACHUSETTS GENERAL HOSPITAL BOSTON — Billions of peripheral white blood cells are produced every day by the regular divisions of hematopoietic stem cells and their descendants in the bone marrow. Under normal circumstances, thousands of stem cells contribute progeny to the blood at any given time, making white blood cells a group with diverse ancestry. ...
