Highlights • FGL improves cognition by activating the PKC pathway, and by enhancing the delivery of AMPA receptors to synapses. • PTD4-PI3KAc activates the PI3K signaling to promote synapse and spine formation, enhancing hippocampal dependent memory. • PTEN-PDZ prevents pathological PTEN interactions at synapses and prevents memory deterioration in Alzheimer’s models. Abstract The aim of this paper is to present an overview of three peptides...