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Boosting ‘cold shock’ protein in the brain without cooling protects mice against neurodegenerative disease
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Boosting ‘cold shock’ protein in the brain without cooling protects mice against neurodegenerative disease

by University of Cambridge Alternative splicing coupled to nonsense-mediated decay is revealed to control cold-induced expression of the neuroprotective protein RBM3. Inducing RBM3 by modulating its alternative splicing through ASOs at normothermia is neuroprotective in vivo and has great therapeutic potential. Credit: EMBO Molecular Medicine (2023). DOI: 10.15252/emmm.202217157 Scientists in Cambridge and Berlin have used a form...