by Bill Hathaway, Yale University Credit: Pixabay/CC0 Public DomainAn overly robust immune response to usually harmless germs has been linked to colitis, a potentially severe inflammation of the colon that afflicts millions of people worldwide. A new Yale-led study not only reveals that the presence of one class of fatty acids is the hidden villain that...
by King’s College London Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0New King’s College London research reveals that interventions that improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18%, compared to having no mood intervention. Researchers at the...
by Will Cushman, University of Wisconsin-Madison This image shows the effect of pro-inflammatory cytokines on the growth of a mouse intestinal organoid. Intestinal stem cells (red) are indicative of inflammation and Ki67 proteins (green) are associated with tumors. Credit: Ting FuInflammation in the gut can trigger a doom loop of sorts. The condition messes with the...
by UT Southwestern Medical Center Bioengineering and characterization of the immunosuppressive combinational colon-specific immune niche. Credit: Nature Biomedical Engineering (2023). DOI: 10.1038/s41551-023-01136-9By taking advantage of mechanisms that allow cancer cells to evade immune attack, UT Southwestern Medical Center researchers have developed a new strategy in animal models that has potential for treating ulcerative colitis. Their findings, reported...
Studies in mice reveal the mechanism that induces this severe side effect and point to a solution that kills the cancer without causing gastrointestinal issues AuthorNicole Fawcett Jacob Dwyer, Michigan MedicineResearchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment. They also...
The white blood cell TH17 helps the immune system fight infection by promoting inflammation. But it can be too much of a good thing: Excessive inflammation from TH17 overload has been tied to autoimmune disorders, such as inflammatory bowel disease (IBD) and arthritis. Researchers led by Hening Lin, professor of chemistry and chemical biology in the College...
The cells that line the gut of an ulcerative colitis patient are inflamed and filled with a protein called PAI-1 (shown in red) that is linked to blood clotting. Nuclei are shown in blue, and other intestinal cells are marked in green. Researchers at Washington University School of Medicine in St. Louis have found that blocking the...
AUGUSTA, Ga. (Jan. 14, 2019) – Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer. Inflammation is supposed to be a short-term response to an infection or other irritant in the body that is essential to eliminating it. But when...
