INDIANAPOLIS – Researchers have created novel scoring tools for predicting actual risk of colon cancer and advanced precancerous polyps for patients at average for the disease. The work was led by Thomas F. Imperiale, M.D., Regenstrief Institute and U.S. Department of Veterans Affairs research scientist and Indiana University School of Medicine professor of medicine. The...
Tag: <span>Colon Cancer</span>
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Gut bacteria might be an indicator of colon cancer risk
A study published in the journal Cell Host & Microbe reported that the increased presence of certain bacteria in a gut biome indicates a greater likelihood that colon polyps will become cancerous. In his research, William DePaolo, associate professor at the University of Washington School of Medicine, tracked 40 patients who had undergone routine colonoscopies and had biopsies taken near the polyps to identify bacteria...
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Study: Colon cancer risk extends to second- and third-degree relatives
by David J. Hill, University at Buffalo Cancer — Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0 Having second- or third-degree relatives with colorectal cancer increases a person’s risk of developing the disease, according to the findings of a study led by researchers from the University at Buffalo and the University of Utah. Early colonoscopy...
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Researchers discover a gene that controls the severity of colon cancer
by Brittany Steff, Purdue University Majid Kazemian and a team of scientists have discovered that the gene TCF-1 plays a key role in controlling TReg cells, affecting the severity of colon cancer. Credit: Purdue University / Rebecca McElhoe Regulatory T cells (TReg) are essential to regulating the immune system. However, there are several different types of...
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Study shows new links between high fat diets and colon cancer
by Arizona State University Credit: CC0 Public Domain For decades, physicians and dieticians have urged people to limit their intake of high-fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease, and cancer. According to the Centers for Disease Control and Prevention,...
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Research shows for the first time that protein complexes ‘inflammasomes’ are linked to obesity-related colon cancer
EUROPEAN ASSOCIATION FOR THE STUDY OF OBESITY New research presented at this year’s European Congress on Obesity (held online, 10-13 May) finds evidence that structures called inflammasomes (a part of the innate immune system that helps to regulate inflammation) could play an important role in the development of obesity-associated colon cancer. The study is by Dr Victoria...
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City of Hope developed cancer-killing virus: activates immune system against colon cancer
CITY OF HOPE DUARTE, Calif. — A cancer-killing virus that City of Hope scientists developed could one day improve the immune system’s ability to eradicate tumors in colon cancer patients, reports a new study in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research. The preclinical research is a first step to showing that City of...
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New prognostic markers for colon cancer identified
by Johannes Angerer, Medical University of Vienna Electron microscopic image of a single human lymphocyte. Gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures (ILSs). Additionally, researchers have shown that in the course of cancer, ectopic lymphoid structures (ELSs; also known as tertiary...
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Scientists discover second key pathway in colon cancer stem cell growth
by ChristianaCare From left: Lynn Opdenaker, Ph.D., Brian Osmond, Bruce Boman, M.D., Chi Zhang, Victoria Hunsu, Caroline Facey, Ph.D. Credit: ChristianaCare In breakthrough colon cancer research, scientists at ChristianaCare’s Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is...
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Study reveals how cannabinoids may be useful to prevent colon cancer
by University of South Carolina Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0 Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis are caused by unrestrained inflammation of the gastrointestinal tract. Patients with IBD are at a higher risk of developing colorectal...