AUGUSTA, Ga. (Jan. 14, 2019) – Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer. Inflammation is supposed to be a short-term response to an infection or other irritant in the body that is essential to eliminating it. But when...
Tag: <span>Colon Cancer</span>
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Larotrectinib: Targeting DNA in cancer therapy
While other toddlers her age were fighting naptime, two-year-old Michelle was battling an aggressive, life-threatening cancer. Doctors at Children’s Hospital Los Angeles saved her life in an epic battle, wielding what is being hailed as a “magic bullet” in the fight against certain cancers. Michelle, 2, participated in the clinical trial for larotrectinib at Children’s Hospital Los...
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New study finds that inflammatory proteins in the colon increase incrementally with weight
BOSTON (Oct. 10, 2018)–Studies in mice have demonstrated that obesity-induced inflammation contributes to the risk of colorectal cancer, but evidence in humans has been scarce. A new study shows that two inflammatory proteins in the colon increase in parallel with increasing weight in humans. An incremental rise in these pro-inflammatory proteins (called cytokines) was observed...
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Colon cancer is caused by bacteria and cell stress
The microbiota in the intestines fuels tumor growth TECHNICAL UNIVERSITY OF MUNICH (TUM) “With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation,” explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM. “However, the...
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Swallowable ‘bacteria on a chip’ could help diagnose colon cancer, bowel disorders and gut ulcers
The capsule made by MIT scientists is packed with tiny electronics Unlike other ingestible chips, it contains millions of genetically engineered living cells to act as sensors These cells are designed to light up when they detect bleeding The chip might someday be used to spot health problems from inside the gut Scientists have developed...
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Certain iron supplements may influence the development of colon cancer
Two common iron compounds increase the formation of a known biomarker for cancer, according to a new study of cancer cells from Chalmers University of Technology, Sweden IMAGE: FERRIC CITRATE AND FERRIC EDTA, ARE OFTEN USED IN DIETARY SUPPLEMENTS AND AS A FOOD ADDITIVE RESPECTIVELY, IN WORLDWIDE MARKETS INCLUDING THE USA AND THE EU Two common...
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Researchers find new trigger for onset of colon cancer, which may lead to better therapies
Colon cancer is the second most common cause of cancer-related deaths. The APC protein has long been known for its critical role in preventing colorectal cancer. When APC is inactivated, the development of colorectal cancer is triggered. Inactivation of APC is responsible for the vast majority (80%) of all colorectal cancers. Researchers from the laboratory...
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Study suggests colon cancer cells carry bacteria with them when they metastasize
(Medical Xpress)—A team of researchers working at Harvard University has found evidence that suggests a certain type of bacteria found in colon cancer tumors makes its way to tumors in other body parts by traveling with the metastasizing cells. In their paper published in the journal Science, the group describes their study of the bacteria and...
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COLON CANCER: APC PROTEIN AFFECTS IMMUNITY BY PREVENTING PRE-CANCEROUS INFLAMMATION
Adenomatous polyposis coli (APC) is a gene whose mutations are associated with a rare, hereditary form of colorectal cancer known as familial adenomatous polyposis. Research led by scientists at the Institut Pasteur, CNRS and Inserm have recently demonstrated that mutations to this gene do not only lead to the emergence of colon polyps; they also...
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New study offers novel treatment strategy for patients with colon cancer
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. In a new study, researchers demonstrate for the first time that a previously uncharacterized protein is increased in colon cancer. The protein is immunoglobulin containing proline rich receptor-1 (IGPR-1) which was recently identified in the same laboratory as a cell adhesion molecule. The new findings, reported...