Walter Alexander June 01, 2023 CHICAGO – The regular use of aspirin or other nonsteroidal anti-inflammatory drugs was found to be associated with a lower risk of early-onset conventional and advanced adenomas. The authors say that aspirin could prove to be an effective strategy in preventing early-onset colorectal cancer cases. “What we have here is a 15% reduction for...
Tag: <span>Colorectal Cancer</span>
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Key Red Flags for Early-Onset Colorectal Cancer
Megan Brooks May 11, 2023 As the number of cases of early-onset colorectal cancer (CRC) diagnosed before age 50 continues to rise, early detection has become increasingly important. A new study has identified four signs and symptoms that can serve as red flags to facilitate earlier detection of early-onset CRC. The signs and symptoms are abdominal pain, rectal bleeding, diarrhea,...
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Gene p16, which drives colorectal cancer, is emerging as a target for potential therapies
by Homa Shalchi, Baylor College of Medicine Engineered p16 epimutation recapitulates key features of age-associated epigenetic silencing. A p16 DNA methylation profiles in cis-MEF following serial passaging (p). A schematic of the p16 promoter of the cis-element knock-in allele with the CpG maps is shown. B Kinetics of p16 promoter methylation and mRNA expression in ctr-MEF and cis-MEF. Methylation levels were averaged from CpGs from − 814 bp to − 589 bp relative to the TSS....
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4 RED FLAGS SIGNAL EARLY-ONSET COLORECTAL CANCER RISK
These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled in recent years. For the study in the Journal of the National Cancer Institute, researchers looked at de-identified health insurance data on more than 5,000 patients with early-onset colorectal...
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Obesity as a risk factor for colorectal cancer underestimated so far, says study
by German Cancer Research Center Weight Change Among Cases and Controls Within 12 Years Before Diagnosis/Interview Lower and upper hinges correspond to 25th and 75th quantile of weight changes, respectively; lower and upper whiskers correspond to 5th and 95th quantile, respectively; outliers not shown. Credit: JAMA Network Open (2023). DOI: 10.1001/jamanetworkopen.2023.9556 Obesity is a known risk factor for...
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Study unravels pathophysiological role of Dectin-1 in promoting colorectal cancer
by Tokyo University of Science Mouse model of familial colorectal adenomatosis (ApcMin) showing significantly fewer colonic polyps in Dectin-1-deficient (Clec7a–/–) mice; B. Polyps show reduced expression of PGE2 synthase (Cox2). In vitro, Cox2 expression is induced in myeloid cells by curdlan—a high-molecular-weight β-glucan—and conversely inhibited by laminarin—a low-molecular-weight β-glucan; C. Increased IL-22BP expression in Clec7a–/– mice;...
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Sox9 protein enables molecular ‘time travel’ that can lead to colorectal cancer
by Dana-Farber Cancer Institute Elevated expression of Sox9 and reduced expression of differentiation genes in murine models of intestinal neoplasia. A. Diagram showing breeding scheme to achieve Lgr5-Apcf/f-tdT mice for conditional Apc inactivation. B. Representative images showing gross anatomy of duodenal intestines from indicated mice. C. Heat map of intestinal stem cell (red) and differentiation...
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Personalized gut microbiome analysis for colorectal cancer classification with explainable AI
by Tokyo Institute of Technology Graphical abstract. Credit: Tokyo Tech The gut microbiome comprises a complex population of different bacterial species that are essential to human health. In recent years, scientists across several fields have found that changes in the gut microbiome can be linked to a wide variety of diseases, notably colorectal cancer (CRC)....
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How Fecal DNA Testing can Help with Early Detection of Colorectal Cancer
Sponsored Content by BGI Genomics Feb 10 2023 Overview of the Current Colorectal Cancer Landscape Colorectal cancer is the third most common cancer worldwide, with over 1.9 million new cases in 2020, and is also the third most common cause of cancer-related mortality.1 Colorectal cancer rates are particularly high in the developed world, and alarmingly, the...
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How Fecal DNA Testing can Help with Early Detection of Colorectal Cancer
Colorectal cancer is the third most common cancer worldwide, with over 1.9 million new cases in 2020, and is also the third most common cause of cancer-related mortality.1 Colorectal cancer rates are particularly high in the developed world, and alarmingly, the rates are increasing in many other countries as well, with changing dietary habits thought to...