ROCKEFELLER UNIVERSITY PRESS Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it...
Tag: <span>Colorectal Cancer</span>
Post
Unexpected role of mTORC2 protein in colorectal cancer
by Johannes Angerer, Medical University of Vienna New results from researchers at MedUni Vienna’s Center for Pathobiochemistry and Genetics show that a protein called mTORC2, which is the target of newly developed cancer drugs, is not even active in colorectal cancer. mTORC2 activity was only found in certain immune cells, which actually need this protein...
Post
An inflammatory diet correlates with colorectal cancer risk
by IDIBELL-Bellvitge Biomedical Research Institute Researchers from the Molecular Mechanisms and Experimental Therapy in Oncology program (Oncobell) of the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO), together with the Biodonostia Health Research Institute (IIS Biodonostia), among others, have published in Nutrients the results of a multicenter study that unveils a correlation between inflammatory and antioxidant...
Post
Right combination of diet and bacteria limits cancer progression
by University of Luxembourg Diet can have significant effects on the gut microbiome, the populations of microorganisms such as bacteria that live in the human gut. It is well recognised that through complex metabolic interactions, dietary habits contribute to cancer prevention. More specifically, diets rich in fibre reduce the risk of developing specific cancers such as...
Post
Microbial Signature for Colorectal Cancer Identified Using Machine Learning
Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, the University of Trento in Italy, and other international collaborators leveraged a machine learning algorithm to identify a subset of gut bacteria associated with colorectal cancer, the third most common cancer worldwide. They performed a meta-analysis of eight studies of gut bacteria and colorectal...
Post
Insulin protects against colorectal cancer
Excess weight promotes the development of insulin resistance and the incidence of colon cancer. Scientists from the Max Planck Institute for Metabolic Research in Cologne identified a new mechanism of the insulin signaling in the intestinal mucosa, which is responsible for maintaining the intestinal barrier and explains the connection between insulin resistance and intestinal cancer....
Post
Metastatic Colorectal Cancer Linked to Transcription Factors, Gene Networks
NEW YORK (GenomeWeb) – A pair of investigators from China has identified four transcription factors— along with related long non-coding RNAs and target genes — that are suspected of contributing to colorectal cancer (CRC) metastases. As they reported in Scientific Reports yesterday, the researchers used available RNA sequence, array-based genotype, DNA methylation, and mass spectrometry-based protein profile data to analyze samples from nearly 600...
Post
New system for treating colorectal cancer can lead to complete cure
Novel three-step pretargeted radioimmunotherapy offers safe, effective treatment RESTON, Va. – Researchers at Memorial Sloan Kettering Cancer Center in New York City and Massachusetts Institute of Technology in Boston have developed a new, three-step system that uses nuclear medicine to target and eliminate colorectal cancer. In this study with a mouse model, researchers achieved a...
Post
Colorectal cancer: New, less toxic drug target uncovered
A team of researchers at the Francis Crick Institute in London, in the United Kingdom, set out to explore novel therapeutic options for treating bowel cancer. They found a drug target that promises to be less toxic than existing drugs. In the United States, colorectal cancer is expected to affect 135,430 people in 2017, according to the American Cancer Society (ACS)....