by Garvan Institute of Medical Research Bisphosphonate is internalized by alveolar and peritoneal macrophages in vivo. (a) An in vitro prenylation assay detects unprenylated Rab GTPases (uRabs) in bone marrow-derived macrophages after culture for 24 hr with 1, 5, or 10 μM zoledronic acid (ZOL) compared to 1, 5, or 10 μM AF647-ZOL. (b) FACS...
