by University of Texas at El Paso Renato Aguilera, Ph.D., a professor in the Department of Biological Sciences at The University of Texas at El Paso, is the principal investigator on a project that identified a novel pharmaceutical compound that successfully kills leukemia and lymphoma cancer cells, potentially paving the way for new forms of therapy....
Tag: <span>Compound</span>
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New immune system-targeting compound shows early promise in treating lupus
by The Scripps Research Institute Chemoproteomic discovery of SLC15A4 inhibitors. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-023-01527-8Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn’s disease. This protein, known as SLC15A4, has been considered largely “undruggable,” as most...
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Researchers create new cancer fighting compound
by Elizabeth Chapin, University of Kentucky Graphical abstract. Credit: Chemical Communications (2022). DOI: 10.1039/D2CC03081K A University of Kentucky Markey Cancer Center researcher’s team developed new chemical compounds that show promise as a potential anticancer therapy to treat aggressive tumors. The study led by Samuel G. Awuah, Ph.D., was published in Chemical Communications with Adedamola Arojojoye, a graduate student in...
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Team identifies compound with potent antiseizure effects
by Diana Yates, University of Illinois at Urbana-Champaign Researchers found a compound that reduces the excitability of neurons in the hippocampus and reduces epileptic seizures in mice. Credit: Michael Vincent. Researchers studying epileptic seizures of the temporal lobe—the most common type of epilepsy—discovered a compound that reduces seizures in the hippocampus, a brain region where...
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COMPOUND MAY PREVENT ARRHYTHMIA SIDE EFFECT
Many drugs that are effective against cancer, infections, and other diseases, can induce a lengthening of the heart’s electrical event, or action potential, as an adverse side effect. This can render these drugs unsafe or too risky for patients. According to the American Heart Association, heart arrhythmias contribute to about 200,000 to 300,000 sudden deaths a...
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Compound derived from thunder god vine could help pancreatic cancer patients
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE PHOENIX, Ariz. — Dec. 14, 2020 — The results of a pre-clinical study led by researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest how a compound derived from the thunder god vine — an herb used in China for centuries to treat joint pain, swelling and fever — is...