In this interview, Dr. MeiLan Han, a distinguished pulmonologist and Chief of the Division of Pulmonary and Critical Care at the University of Michigan, shares her profound insights into Chronic Obstructive Pulmonary Disease (COPD).With your extensive background and contributions in Pulmonary and Critical Care, can you share what initially drew you to the study of...
Tag: <span>COPD</span>
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Study explores the challenges of the clinical diagnoses of acute exacerbation of chronic obstructive pulmonary disease
By Dr. Priyom Bose, Ph.D. Aug 16 2023 Reviewed by Sophia Coveney A recent BMC Pulmonary Medicine study evaluated the clinical, laboratory, and radiographic characteristics of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). It aimed to distinguish them from other diseases in patients with a history of chronic obstructive pulmonary disease (COPD). Study: Complexity in clinical diagnoses of acute exacerbation of chronic...
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New genetic associations found for COPD in the largest study of its kind
by Justin Jackson , Medical Xpress GRS performance. a, Prediction performance of three GRSs across ancestry groups for FEV1/FVC shown as the s.d. change in FEV1/FVC per s.d. increase in GRS for individuals in the UK Biobank grouped according to ancestry. Sample sizes: AFR, n = 4,227; AMR, n = 2,798; EAS, n = 1,564; and EUR, n = 320,656. b, Prediction performance...
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COPD: New, Simplified Treatment Guidelines
Neil Skolnik, MD January 06, 2023 I’m Dr Neil Skolnik. Today we are going to talk about the 2023 GOLD guide for COPD. The big news here is a more streamlined approach to treatment, combining what used to be categories C and D into one category — E — for exacerbations. There is continued emphasis on getting a...
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New therapeutic approach to COPD involves targeting and inhibiting protein RIPK1
by University of Technology, Sydney Credit: Pixabay/CC0 Public Domain Research led by the Centenary Institute, the University of Technology Sydney and Ghent University Hospital, Belgium has identified a new therapeutic approach for chronic obstructive pulmonary disease (COPD)—the targeting and inhibition of a protein called RIPK1. The third leading cause of death worldwide and with no...
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Some surprisingly good news about Chronic Obstructive Pulmonary Disease (COPD)
by University of Toronto Credit: Pixabay/CC0 Public Domain Chronic Obstructive Pulmonary Disease (COPD)—a debilitating chronic lung disease that includes emphysema and chronic bronchitis—has previously been linked to mental health problems, such as depression, anxiety, and substance use disorders. But a new study by University of Toronto researchers found that, even though adults without the disease...
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USPSTF recommends against screening for COPD in asymptomatic adults
JAMA NETWORK Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends against screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults who do not recognize or report respiratory symptoms. Chronic obstructive pulmonary disease is an irreversible reduction of airflow in the lungs. Progression to severe disease can prevent participation in normal activities because of...
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Two drugs show promise in rejuvenating lung epithelial progenitor cells damaged by COPD
by Bob Yirka, Medical Xpress Overview of the transcriptomics-guided drug discovery strategy.(A) Schematic outline of the drug screening strategy. (B) Heatmap shows the gene expression pattern of the druggable genes (www.dgidb.org) identified both in CS-exposed mice and patient with COPD databases. (C) Reactome pathway enrichment analysis of genes differentially expressed from patients with COPD (8)...
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Researchers produce a cellular blueprint of COPD
Chronic Obstructive Pulmonary Disease, or COPD, is the third leading cause of death worldwide. Yet despite its prevalence, the disease is not well understood on a cellular level. New Yale research has provided an unprecedented atlas of the cells in the COPD-afflicted lung, identifying those cells and pathways that may contribute to the reduced lung...
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Ion channel regulates molecule that contributes to COPD
JANUARY 14, 2022 by Ludwig Maximilian University of Munich Immunofluorescence image of lung tissue showing co-localization of TRPML3 (green) and macrophages (red). Credit: Barbara Spix Chronic obstructive pulmonary disease—COPD for short—is one of the most common diseases of the lung. It affects almost 300 million people worldwide, of which about three million die every year. A...