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Scientists create the first CRISPR-based drug candidate targeting the microbiome
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Scientists create the first CRISPR-based drug candidate targeting the microbiome

by Technical University of Denmark An overview of the SNIPR001 creation process. First, WT phages are screened against a panel of E. coli strains. Then, phages with broad activity against E. coli are tail fiber engineered and/or armed with CRISPR–Cas systems containing sequences specific to E. coli, creating CAPs. These CAPs are then tested for host...