by Liz Ahlberg Touchstone, University of Illinois at Urbana-Champaign Spinal cord astrocytes, the cells seen in this fluorescent microscope image, are involved in the progression of ALS. A new CRISPR-Cas13 system targeting mutant protein production in these cells improved outcomes for mice with ALS. Credit: Thomas Gaj and Colin Lim A single genetic mutation can...
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR), is described today (October 25)...
