by Vanderbilt University Medical Center Credit: CC0 Public Domain A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, Vanderbilt researchers have discovered. They report Nov. 11 in the journal Immunity that inhibiting or genetically deleting the enzyme, called MTHFD2,...
Tag: <span>CRISPR screen</span>
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Full-genome CRISPR screen reveals surprising ways neurons survive oxidative stress
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO IMAGE: SUPER-RESOLUTION MICROSCOPY OF A NEURON SHOWS THE ACCUMULATION OF LIPIDS WITHIN LYSOSOMES THAT OCCURS WHEN THE GENE FOR PROSAPOSIN IS SUPPRESSED. CREDIT: UCSF When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the...