by Marilynn Marchione In this January 2019 image made from video provided by Penn Medicine, IV bags of CRISPR-edited T cells are prepared for administering to a patient at the Abramson Cancer Center in Philadelphia. Early results released on Wednesday, Nov. 6, 2019 show that doctors were able to take immune system cells from the...
Tag: <span>Crispr</span>
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Early Results from First-In-U.S. Trial of CRISPR-Edited Immune Cells for Cancer Patients Suggest Safety of Approach
Abramson Cancer Center researchers to present initial safety data after treating three patients. Genetically editing a cancer patient’s immune cells using CRISPR/Cas9 technology, then infusing those cells back into the patient appears safe and feasible based on early data from the first-ever clinical trial to test the approach in humans in the United States. Researchers...
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New CRISPR tool has the potential to correct almost all disease-causing DNA glitches, scientists report
By SHARON BEGLEY | OCTOBER 21, 2019 A new form of the genome-editing tool CRISPR-Cas9 appears to significantly expand the range of diseases that could be treated with the technology, by enabling scientists to precisely change any of DNA’s four “letters” into any other and insert or delete any stretch of DNA — all more...
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Russian ‘CRISPR-baby’ scientist has started editing genes in human eggs with goal of altering deaf gene
Denis Rebrikov also told Nature that he does not plan to implant gene-edited embryos until he gets regulatory approval. David Cyranoski An earlier version of this story and its headline incorrectly stated that Denis Rebrikov had started editing eggs from a woman with a mutation that causes deafness. Russian biologist Denis Rebrikov has started gene editing in eggs donated by women who can...
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Major error undermines study suggesting change introduced in the CRISPR babies experiment shortens lives
A scientific study published this past spring came with damning implications for Chinese scientist He Jiankui, who created the world’s first gene-edited babies: People with the rare genetic variants that He tried to engineer into embryos, the study asserted, had an increased death rate. On Friday, the paper’s senior author said his study was wrong....
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Forget single genes: CRISPR now cuts and splices whole chromosomes
Imagine a word processor that allowed you to change letters or words but balked when you tried to cut or rearrange whole paragraphs. Biologists have faced such constraints for decades. They could add or disable genes in a cell or even—with the genome-editing technology CRISPR—make precise changes within genes. Those capabilities have led to recombinant DNA technology, genetically modified organisms, and...
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CRISPR-Responsive Materials Deliver Therapy on Biological Cues
CRISPR gene editing is a technique famous for its potential to edit the genomes of living organisms, including humans. Using the technique, it may be possible to reverse congenital conditions, kill off viruses, and do things previously only imagined. But now it has been employed to do something else entirely, and that is to give...
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Deadly box jellyfish antidote discovered using CRISPR genome editing
by University of Sydney Researchers at the University of Sydney have discovered an antidote to the deadly sting delivered by the most venomous creature on earth—the Australian box jellyfish. The Australian box jellyfish (Chironex fleckeri) has about 60 tentacles that can grow up to three metres long. Each tentacle has millions of microscopic hooks filled with venom. Each box jellyfish carries enough venom to kill more than 60 humans. A single...
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CRISPR base editing, known for precision, hits a snag with off-target mutations
The version of CRISPR whose selling point has been its precision suffers, ironically, from the same shortcoming that has dogged other forms of the genome editor — that it makes a lot of unintended, off-target DNA changes. In two studies published on Thursday, one in mice embryos and one in rice plants, scientists find that...
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Researchers overcome hurdle in CRISPR gene editing for muscular dystrophy
The gene editing technique known as CRISPR is a revolutionary approach to treating inherited diseases. However, the tool has yet to be used to effectively treat long-term, chronic conditions. A research team led by Dongsheng Duan, Ph.D., at the University of Missouri School of Medicine has identified and overcome a barrier in CRISPR gene editing...