Peer-Reviewed Publication Boston Children’s Hospital FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Crohn’s disease, a debilitating inflammatory bowel disease, has many known contributing factors, including bacterial changes in the microbiome that foster an inflammatory environment. Now, for the first time, Crohn’s disease has been tied to a virus — specifically, Epstein-Barr virus (EBV), best known for causing infectious mononucleosis (mono). Researchers...
Tag: <span>Crohn’s disease</span>
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Microbiome as a potential key to better treatment: Clinical study on new therapy for Crohn’s disease
Peer-Reviewed Publication Technical University of Munich (TUM) FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Prof. Dr. Dirk Haller (left) and PD Dr. Tobias Schwerd examine one of the cultured samples from the research project on exclusive enteral nutrition for Crohn’s disease. Prof. Dr. Dirk Haller is a Professor of Nutrition and Immunology at TUM and director of the ZIEL –...
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FDA approves Omvoh for moderately to severely active Crohn’s disease
by Elana Gotkine The U.S. Food and Drug Administration has approved Eli Lilly’s Omvoh (mirikizumab-mrkz) for the treatment of moderately to severely active Crohn’s disease in adults. Omvoh targets interleukin-23p19, which contributes to intestinal inflammation. Omvoh is the first biological treatment for Crohn’s disease to have disclosed two-year Phase III efficacy data at the time...
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New understanding of the gut immune system may hold promise for Crohn’s disease patients
A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn’s disease. The discovery may help define how to treat patients with severe Crohn Peer-Reviewed PublicationTECHNICAL UNIVERSITY OF DENMARK Tricks played by certain disease-driving gut bacteria might help...
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New study on promising stem cell-based therapy for Crohn’s disease
by Liam Connolly, UC Davis Schematic showing putative mechanism of hMSCs mediated immunosuppression in experimental model of Crohn’s disease. Credit: npj Regenerative Medicine (2024). DOI: 10.1038/s41536-024-00347-1A stem cell therapy for Crohn’s disease developed by UC Davis Health researchers has shown promising results in mouse studies. The research, published in npj Regenerative Medicine, showed that human bone...
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First comprehensive guideline on using biomarkers for monitoring Crohn’s disease
by American Gastroenterological Association Credit: Nephron/WikipediaThe American Gastroenterological Association (AGA) has released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn’s disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S. The guideline was published today in Gastroenterology. Biomarkers...
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When are biologic drugs an option for Crohn’s disease?
Many different types of medications help treat Crohn’s disease, including a group of drugs known as biologics. Doctors often prescribe them for people with moderate to severe symptoms caused by Crohn’s disease. Crohn’s disease is a chronic inflammatory bowel disease (IBD) that causes episodic inflammation, swelling, and irritation within the digestive tract. There is no...
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Single-cell analysis of Crohn’s disease reveals a detailed picture of inflammation in the gut
by Allessandra DiCorato, Broad Institute of MIT and Harvard Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.01.002 Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn’s disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal...
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Study may have solved a mystery surrounding Crohn’s disease
Reviewed by Emily Henderson, B.Sc. Oct 5 2022 A new study may have solved a mystery surrounding Crohn’s disease, a type of inflammatory bowel disease in which immune defenses meant to attack invading microbes instead mistakenly target the body’s own digestive tract. Norovirus, a common infection that causes vomiting and diarrhea, is one of several...
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Norovirus link to Crohn’s disease may point to new therapies
NYU LANGONE HEALTH / NYU GROSSMAN SCHOOL OF MEDICINE A new study may have solved a mystery surrounding Crohn’s disease, an inflammatory bowel illness where immune defenses, meant to attack invading microbes, instead mistakenly target the body’s own digestive tract. Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and...