A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn’s disease. The discovery may help define how to treat patients with severe Crohn Peer-Reviewed PublicationTECHNICAL UNIVERSITY OF DENMARK Tricks played by certain disease-driving gut bacteria might help...
Tag: <span>Crohn’s disease</span>
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New study on promising stem cell-based therapy for Crohn’s disease
by Liam Connolly, UC Davis Schematic showing putative mechanism of hMSCs mediated immunosuppression in experimental model of Crohn’s disease. Credit: npj Regenerative Medicine (2024). DOI: 10.1038/s41536-024-00347-1A stem cell therapy for Crohn’s disease developed by UC Davis Health researchers has shown promising results in mouse studies. The research, published in npj Regenerative Medicine, showed that human bone...
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First comprehensive guideline on using biomarkers for monitoring Crohn’s disease
by American Gastroenterological Association Credit: Nephron/WikipediaThe American Gastroenterological Association (AGA) has released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn’s disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S. The guideline was published today in Gastroenterology. Biomarkers...
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When are biologic drugs an option for Crohn’s disease?
Many different types of medications help treat Crohn’s disease, including a group of drugs known as biologics. Doctors often prescribe them for people with moderate to severe symptoms caused by Crohn’s disease. Crohn’s disease is a chronic inflammatory bowel disease (IBD) that causes episodic inflammation, swelling, and irritation within the digestive tract. There is no...
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Single-cell analysis of Crohn’s disease reveals a detailed picture of inflammation in the gut
by Allessandra DiCorato, Broad Institute of MIT and Harvard Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.01.002 Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn’s disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal...
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Study may have solved a mystery surrounding Crohn’s disease
Reviewed by Emily Henderson, B.Sc. Oct 5 2022 A new study may have solved a mystery surrounding Crohn’s disease, a type of inflammatory bowel disease in which immune defenses meant to attack invading microbes instead mistakenly target the body’s own digestive tract. Norovirus, a common infection that causes vomiting and diarrhea, is one of several...
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Norovirus link to Crohn’s disease may point to new therapies
NYU LANGONE HEALTH / NYU GROSSMAN SCHOOL OF MEDICINE A new study may have solved a mystery surrounding Crohn’s disease, an inflammatory bowel illness where immune defenses, meant to attack invading microbes, instead mistakenly target the body’s own digestive tract. Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and...
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Study zeroes in on genes involved in Crohn’s disease
by Wellcome Trust Sanger Institute Credit: CC0 Public Domain An international consortium of researchers has identified genetic variants in 10 genes that elevate a person’s susceptibility to Crohn’s disease, a form of inflammatory bowel disease. Led by researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard, the study is the largest...
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New insights into the mechanisms behind Crohn’s disease point to potential therapeutic target
by Massachusetts General Hospital Credit: Hajera Amatullah et al, Cell (2022). DOI: 10.1016/j.cell.2022.06.048 The structure of chromatin—the mixture of DNA and proteins that form chromosomes—can affect gene expression, and certain chromatin “readers” are important for monitoring this structure often in response to environmental cues. Mutations within one such reader, called Speckled Protein 140 (SP140), are associated with an...
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Two new treatments for Crohn’s disease equally effective
by Will Doss, Northwestern University High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Two new treatments for Crohn’s disease showed roughly equal performance in a clinical trial, according to findings published in The Lancet. This allows clinicians and patients to make treatment choices based on tolerance, according to Stephen Hanauer, MD, the Clifford...