by Wellcome Trust Sanger Institute Credit: CC0 Public Domain An international consortium of researchers has identified genetic variants in 10 genes that elevate a person’s susceptibility to Crohn’s disease, a form of inflammatory bowel disease. Led by researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard, the study is the largest...
by Massachusetts General Hospital Credit: Hajera Amatullah et al, Cell (2022). DOI: 10.1016/j.cell.2022.06.048 The structure of chromatin—the mixture of DNA and proteins that form chromosomes—can affect gene expression, and certain chromatin “readers” are important for monitoring this structure often in response to environmental cues. Mutations within one such reader, called Speckled Protein 140 (SP140), are associated with an...
by Will Doss, Northwestern University High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Two new treatments for Crohn’s disease showed roughly equal performance in a clinical trial, according to findings published in The Lancet. This allows clinicians and patients to make treatment choices based on tolerance, according to Stephen Hanauer, MD, the Clifford...
by Jim Oldfield, University of Toronto Illustration of bacteria in the human gut. Credit: Darryl Leja, National Human Genome Research Institute, National Institutes of Health An international team led by a University of Toronto researcher has found that an antibody detectable in blood predicts severe Crohn’s disease and is detectable up to seven years prior...
CORNELL UNIVERSITY ITHACA, N.Y. — A multi-year study of the role of E. coligut bacteria in Crohn’s disease finds that intestinal inflammation liberates chemicals that nourish the bacteria’s growth and promotes their ability to cause inflammation. The results identify new avenues for treatments that selectively disrupt the compounds that feed E. coli. The study, “Mucosal Metabolites...
Crohn’s disease is a type of inflammatory bowel disease (IBD). Its incidence and the increased risk of other conditions or complications are different in males and females. Although symptoms and treatment may vary, these differ for each individual, rather than across age or gender. The Good Brigade/Getty Images Crohn’s disease is a chronic condition that causes...
by Stony Brook University IL-17A acts on unique cell types to regulate intestinal function. Under normal conditions, IL-17A acts on stem cells to promote their differentiation into secretory epithelial cells. This visual depicts that during colitis, IL-17A acts on secretory cells to mitigate the disease’s inflammatory effects. Credit: Pawan Kumar A paper published this week...
by Bob Yirka, Medical Xpress Fig. 1: Psychological stress promotes the expansion of ileal Enterobacteriaceae. a Schematic representation of the stress protocol and legend of bacterial phylum and family. Taxonomy plots of 16S rRNA sequencing of the ileal (b), cecal (c), or colonic (d), contents of naive (n = 4), starved (food and water deprived, n = 4), and...
by McMaster University Former McMaster post-doctoral researcher Ryan Shaler, left, and professor Brian Coombes work together in the lab. Credit: McMaster University A possible link between psychological stress and Crohn’s disease flare-ups has been identified by a McMaster University-led study. Researchers using mouse models found that stress hormones suppressed the innate immune system that normally protects the gut...
by McMaster University Fig. 1. Effects of reduced 5-HT on autophagy in the whole colon of mice with DSS-induced colitis.DSS (5%) was given to Tph1+/+ and Tph1−/− mice in drinking water for 5 days to induce colitis. Control groups received autoclaved drinking water. Each group contained three to five mice. (A) DAI. *P < 0.05...
