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Cellular ‘cruise control’ system safeguards RNA levels in Rett syndrome nerve cells
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Cellular ‘cruise control’ system safeguards RNA levels in Rett syndrome nerve cells

by The Hospital for Sick Children Cis-acting elements in the 3ʹUTR are highly associated with half-life changes. a Random forest classifier for prediction of mRNA sequence features relevant for half-life fold-change in human NEURTT and in cortical brain samples of the mouse Mecp2 y/-. Percent accuracy (Y-axis) of half-life fold-change predictions in human NEURTT (b) from 2 replicates or...