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A revolution in crystal structure prediction of pharmaceutical drugs
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A revolution in crystal structure prediction of pharmaceutical drugs

Physicists from the University of Luxembourg together with experts from Avant-garde Materials Simulation (AMS) and seven pharmaceutical companies have redefined the state-of-the-art in modeling and predicting the free energy of crystals.Peer-Reviewed Publication UNIVERSITY OF LUXEMBOURG BOLD ROMAN NUMERALS INDICATE METHODS FOLLOWING (I) HERMANN ET AL.39 AND HOJA ET AL.4, AND (II) GREENWELL, ET AL.29. CREDIT:...

Researchers determine first crystal structure of LAG3 protein; findings could yield better cancer therapy approaches
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Researchers determine first crystal structure of LAG3 protein; findings could yield better cancer therapy approaches

by H. Lee Moffitt Cancer Center & Research Institute LAG3 Crystal Structure. Credit: Moffitt Cancer Center Immune checkpoint inhibitors have revolutionized cancer care. The therapy works by preventing tumors from shutting down the immune response, which in turn allows T cells to kill cancer cells. Established checkpoint inhibitors target the proteins PD-1 and CTLA-4 and...