by Julie Crljen, University of Toronto An image of the bile duct cells, or cholangiocytes, derived from stem cells. Credit: Mina Ogawa Researchers at the University of Toronto and its partner hospitals have discovered a way to generate functional cells from stem cells that could open new treatment avenues for people with cystic fibrosis who have...
WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD IMAGE: THIS IMAGE SHOWS HOW NEUTROPHILS (FLUORESCING IN GREEN) THAT WERE ADDED TO THE BLOOD CHANNEL HAVE ATTACHED THEMSELVES TO THE ENDOTHELIUM (WITH CELLS OUTLINED WITH A MARKER SHOWN IN MAGENTA) AND TRANSMIGRATE TO THE EPITHELIUM IN THE PARALLEL CHANNEL. CREDIT: WYSS INSTITUTE AT HARVARD UNIVERSITY Cystic...
by International Society for Stem Cell Research New therapy screening assay showing functional rescue of lung progenitor cells from a person with Cystic Fibrosis caused by nonsense mutation (W1282X). Credit: Christine Bear, Hospital for Sick Kids and University of Toronto, Canada Stem cell researchers may soon have a new way to identify and develop novel,...
Researchers at the Children’s Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the...
by Jeff Hansen, University of Alabama at Birmingham This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable. Credit: Cystic Fibrosis Foundation An experimental drug reported in Nature Communications suggests that a “path is clearly achievable” to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes...
Cystic fibrosis is a genetic, progressive disease that causes persistent lung infections and impacts the most basic physical processes. While recent breakthroughs have significantly extended the lifespan of patients with CF, the disease presents patients and their caregivers with significant, lifelong daily challenges. The primary purpose of cystic fibrosis clinics is to treat the physical...
UNIVERSITY OF SOUTH AUSTRALIA IMAGE: AFTER FOUR HOURS, IF THE INFECTION IS NOT TREATED IT KILLS ALL THE CELLS (LINE 1); UNFORMULATED TOBRAMYCIN KEEPS THE CELLS ALIVE, BUT IT DOES NOT ERADICATE THE INFECTION (LINE 2); NANO-ENHANCED TOBRAMYCIN ERADICATES THE INFECTION. CREDIT: UNISA World-first nanotechnology developed by the University of South Australia could change the...
ANN & ROBERT H. LURIE CHILDREN’S HOSPITAL OF CHICAGO An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least...
by Bob Yirka , Medical Xpress Credit: CC0 Public Domain A team of researchers affiliated with multiple institutions in Germany has developed a type of gene therapy that could be used to help people with cystic fibrosis. In their paper published in the journal Nature Nanotechnology, the group describes how they developed a new class of non-viral gene...
by University of Montana UM researcher Laura Jennings helped discover a strategy used by bacteria to defeat antibiotics and other drugs used to fight infections caused by cystic fibrosis. Credit: University of Montana University of Montana researchers and their partners have discovered a slimy strategy used by bacteria to defeat antibiotics and other drugs used to combat infections...
