People with cystic fibrosis, or CF, don’t appear to be especially susceptible to COVID-19, and when they do get infected, they don’t seem to get sicker, based on clinical data so far. But Ruobing (Ruby) Wang, an assistant professor of paediatrics at Harvard Medical School who cares for patients with CF at Boston Children’s Hospital, thinks...
UNIVERSITY OF WARWICK Staphylococcus aureus (which includes MRSA) is the most prevalent organism isolated from the airways of children with cystic fibrosis (CF), and is treated using antibiotics, but its role in lung disease is poorly understood Using pig lungs from a butcher and synthetic mucus, researchers from the University of Warwick have shown that S. aureus preferentially colonises mucus,...
MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS IMAGE: FIELD AND PROVIDES ALL-INCLUSIVE ACCESS TO THE CRITICAL PILLARS OF HUMAN GENE THERAPY: RESEARCH, METHODS, AND CLINICAL APPLICATIONS. New Rochelle, NY, October 8, 2020–The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation. CF clinical trials showing...
More than 10 million Americans are CF carriers, suggesting the burden of illness from CF-related conditions could be substantial UNIVERSITY OF IOWA HEALTH CARE Conventional wisdom says that having just one mutated copy of the cystic fibrosis gene has no effects on a person’s health–the disease occurs when both copies of the gene are mutated....
by Michele Munz Amy Chastain didn’t think she would be able to be a mom. She didn’t think her child would be born with the same debilitating disease as her. She didn’t think she would live long enough to see this day, when a drug could change her life and most importantly, her son’s. At...
UNIVERSITY OF CALIFORNIA – SAN DIEGO Cystic fibrosis is caused by an inherited mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Due to this mutation, the CFTR protein doesn’t embed in cell membranes to form a channel for chlorine ions the way it should. As a result, mucus-producing cells secrete a thicker-than-normal mucus...
DALLAS – Oct. 31, 2019 – A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease. Earlier this month, the Food and Drug Administration approved...
By DAMIAN GARDE @damiangarde Thirty patients have died after taking a Vertex (VRTX) Pharmaceuticals treatment for cystic fibrosis, according to a government database, news that sent the company’s share price down as much as 4% on Wednesday morning. The deaths, reported to the Food and Drug Administration’s database of side effects, relate to patients who...
Sponsored Content by Neem Biotech How much of a problem are respiratory infections in chronic conditions such as cystic fibrosis, bronchiectasis and COPD? In cystic fibrosis, COPD and people with bronchiectasis, there is a chronic infection that we know now is quite complex and is made up of communities of different species of microbiota; not just bacteria, but also fungi and viruses. It is...
By Monica Beyer Fact checked by Paula Field Researchers say a drug that is already available on the market can help those affected by cysticfibrosis. Amphotericin, which is an antifungal medication, might help people with cystic fibrosis fight the chronic bacterial lunginfections that tend to occur with this disease, according to a recent study. “The really exciting news is that amphotericin is a...
