New research, published in Nature Scientific Reports, conducted by the University and partners highlights effective methods for identifying a common side effect in children receiving drug treatments for Cystic fibrosis. The genetic disorder, cystic fibrosis (CF) is characterized by secondary bacterial lung infections, often by a specific resistant bacteria, Pseudomonas aeruginosa. Antibiotics known as aminoglycosides have good efficacy...
Tag: <span>cystic fibrosis</span>
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Gene panel predicts course of cystic fibrosis
Researchers at National Jewish Health have identified 10 immune-related genes whose activity during a respiratory infection predict the long-term prognosis for cystic fibrosis patients better than conventional measures. Five years after being evaluated, patients in the lowest-risk group were all alive and doing well, whereas 90 percent of patients in the highest risk cluster...
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Fighting cystic fibrosis with CFTR amplifier
CAMBRIDGE, Mass.—Proteostasis Therapeutics Inc. (PTI), a clinical stage biopharmaceutical company dedicated to the discovery and development of groundbreaking therapies to treat cystic fibrosis (CF) and other diseases caused by dysfunctional protein processing, announced a few days ago that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation for PTI-428, the Company’s cystic fibrosis transmembrane conductance...
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Discovery of a key molecule for improving cystic fibrosis treatments
Researchers at the University of Montreal Hospital Research Centre (CRCHUM) have identified a promising solution to improving treatments offered to patients with cystic fibrosis. This advancement, published in Frontiers in Cellular and Infection Microbiology, could lead to the development of new personalized therapies in the near future. “Adding molecules called quorum-sensing inhibitors to current drugs...
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Microbiologists uncover clues to clustering of lethal bacteria in CF patients’ lungs
Gregory G. Anderson, PhD, Associate Professor of Biology, Indiana University-Purdue University Indianapolis. Individuals with cystic fibrosis, or CF, have a high risk of chronic pneumonia because the thick, sticky mucus that builds up in their lungs provides an environment conducive to the growth of pneumonia-causing bacteria. Once chronic pneumonia develops, it is nearly impossible...
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An end to the agony of trying uncertain drugs? Scientists can now grow ‘mini organs’ for each patient to see how it reacts to new untested treatment
A lab in Holland is using mini organs for cystic fibrosis sufferers to see how a drug would affect them without putting them through the risks of trying it Els van de Heijden, 53, was able to take an unproven drug after scientists tested it on a lab-grown version of her gut The move is...
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Vitamins could help treat cystic fibrosis, research finds
Researchers from Queen’s University Belfast have discovered why antibiotics for treating people with cystic fibrosis are becoming less effective and how fat soluble vitamins might offer a viable solution. A team of researchers led by Professor Miguel Valvano, from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, has discovered why some particularly harmful...
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Drug combination improves lung function within 15 days of treatment for children with cystic fibrosis
A combination of two drugs – lumacaftor and ivacaftor – improves lung function in children aged 6-11 with cystic fibrosis within 15 days of treatment, according to a phase 3 trial published in The Lancet Respiratory Medicine journal and presented at the European Cystic Fibrosis Society conference. Cystic fibrosis is a genetic disease that causes the lungs and digestive...
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Scientists uncover interactions between bacteria that infect the lungs in cystic fibrosis
Substances produced by a harmful bacterium in the lungs of cystic fibrosis patients may enhance the growth of other bacteria that, in turn, inhibit the harmful bacterium’s biofilm, according to new research published in PLOS Pathogens. Substances produced by a harmful bacterium in the lungs of cystic fibrosis patients may enhance the growth of other...
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Wearable sweat sensor can diagnose cystic fibrosis, study finds
A wearable sensor developed by Stanford researchers can diagnose diseases by measuring molecular constituents of sweat, such as chloride ions and glucose. A wristband-type wearable sweat sensor could transform diagnostics and drug evaluation for cystic fibrosis, diabetes and other diseases. The sensor collects sweat, measures its molecular constituents and then electronically transmits the results for...