OSAKA CITY UNIVERSITY IMAGE: 6His tagged recombinant human CYGB (His-CYGB) was endocytosed into the HSCs via Clathrin-mediated pathway, scavenged ROS, such as O2- and OH-, and induced IFN-β secretion mediated by TANK binding kinase 1 (TBK1), resulting in HSC deactivation and inhibition of αSMA and collagen gene expressions in vitro and in vivo. In total,...
