Due to the devastating worldwide impact of COVID-19, the illness caused by the SARS-CoV-2 virus, there has been unprecedented efforts by clinicians and researchers from around the world to quickly develop safe and effective treatments and vaccines. Given that COVID-19 is a complex new disease with no existing vaccine or specific treatment, much effort is...
Tag: <span>cytokine</span>
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Preventing ‘cytokine storm’ may ease severe COVID-19 symptoms
For some COVID-19 patients, the body’s immune response may be as destructive as the virus that causes the disease. The persistent high fevers, severe respiratory distress, and lung damage seen in some critically ill patients are all signs of an immune system in overdrive. Now, a new clinical trial will test a treatment that targets...
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Male coronavirus patients with low testosterone levels are MORE likely to die from COVID-19, German hospital finds
By JOE PINKSTONE FOR MAILONLINE German hospital assessed the hormone levels of 45 COVID-19 patients in ICU Found that the vast majority of men admitted had low testosterone levels Testosterone may be able to stop the body’s immune system from going haywire Low levels of the sex hormone are unable to regulate the body’s immune...
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Researchers discover key mechanism of cytokine storm in Castleman disease
by Perelman School of Medicine at the University of Pennsylvania When Castleman Disease patients have a flare of their symptoms, they experience a cytokine storm inside their bodies—a hyper-response from the immune system that can cause a fever, organ failure, and even death. Now researchers at the Perelman School of Medicine at the University of...
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Nanotechnology might help fight deadly ‘cytokine storm’ of COVID-19
by E.j. Mundell, Healthday Reporter For many COVID-19 patients battling for their lives in the ICU, a runaway immune system response—known as a “cytokine storm”—is their primary foe. Doctors have few tools to help tame this hyperinflammatory condition, but early research is suggesting that nanotechnology might safely deliver drugs to affected tissues, quieting the storm....
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Proteins may halt the severe cytokine storms seen in Covid-19 patients
Team designs antibody-like receptor proteins that can bind to cytokines, as possible strategy for treating coronavirus and other infections. One of the defining features of Covid-19 is the excessive immune response that can occur in severe cases. This burst of immune overreaction also called a cytokine storm, damages the lungs and can be fatal. A...
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Designer protein delivers signal of choice
A computational strategy has delivered a redesigned, more stable version of a cytokine protein that mimics the natural protein’s interactions with receptors, opening the way for designer cytokine-based therapeutics. Messenger proteins called cytokines are secreted from cells and travel throughout the body. In the immune system, a cytokine called interleukin-2 (IL-2) delivers signals to receptors...
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Unconventional immune cells trigger disturbed cytokine production in human spondyloarthritis
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) and more recently Interleukin-17 (IL-17) has revolutionized the perspectives of patients suffering from this disease by achieving high levels of therapeutic efficacy. The disease differs substantially from rheumatoid arthritis, another form of...
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Adrenaline fuels a cytokine storm during Immunotherapy
Attempts to boost the body’s antitumour immune responses can trigger a harmful inflammatory reaction called a cytokine storm. New insights into the mechanisms involved might help to prevent this problem. Many newly developed, potent cancer therapies aim to harness an immune response to target tumours1. However, a common problem with such immunotherapy approaches is the development of...
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A potential new way to treat some of the most common blinding diseases
Inhibition of atypical protein kinase C may help manage macular edema and vision loss associated with eye diseases, reports The American Journal of Pathology Philadelphia, PA, September 13, 2018 – Many eye diseases, including diabetic retinopathy and macular degeneration, exhibit an increased permeability of blood vessels in the macula (central) portion of the retina leading...
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