For some COVID-19 patients, the body’s immune response may be as destructive as the virus that causes the disease. The persistent high fevers, severe respiratory distress, and lung damage seen in some critically ill patients are all signs of an immune system in overdrive. Now, a new clinical trial will test a treatment that targets...
By JOE PINKSTONE FOR MAILONLINE German hospital assessed the hormone levels of 45 COVID-19 patients in ICU Found that the vast majority of men admitted had low testosterone levels Testosterone may be able to stop the body’s immune system from going haywire Low levels of the sex hormone are unable to regulate the body’s immune...
by Perelman School of Medicine at the University of Pennsylvania When Castleman Disease patients have a flare of their symptoms, they experience a cytokine storm inside their bodies—a hyper-response from the immune system that can cause a fever, organ failure, and even death. Now researchers at the Perelman School of Medicine at the University of...
by E.j. Mundell, Healthday Reporter For many COVID-19 patients battling for their lives in the ICU, a runaway immune system response—known as a “cytokine storm”—is their primary foe. Doctors have few tools to help tame this hyperinflammatory condition, but early research is suggesting that nanotechnology might safely deliver drugs to affected tissues, quieting the storm....
Team designs antibody-like receptor proteins that can bind to cytokines, as possible strategy for treating coronavirus and other infections. One of the defining features of Covid-19 is the excessive immune response that can occur in severe cases. This burst of immune overreaction also called a cytokine storm, damages the lungs and can be fatal. A...
A computational strategy has delivered a redesigned, more stable version of a cytokine protein that mimics the natural protein’s interactions with receptors, opening the way for designer cytokine-based therapeutics. Messenger proteins called cytokines are secreted from cells and travel throughout the body. In the immune system, a cytokine called interleukin-2 (IL-2) delivers signals to receptors...
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) and more recently Interleukin-17 (IL-17) has revolutionized the perspectives of patients suffering from this disease by achieving high levels of therapeutic efficacy. The disease differs substantially from rheumatoid arthritis, another form of...
Attempts to boost the body’s antitumour immune responses can trigger a harmful inflammatory reaction called a cytokine storm. New insights into the mechanisms involved might help to prevent this problem. Many newly developed, potent cancer therapies aim to harness an immune response to target tumours1. However, a common problem with such immunotherapy approaches is the development of...
Inhibition of atypical protein kinase C may help manage macular edema and vision loss associated with eye diseases, reports The American Journal of Pathology Philadelphia, PA, September 13, 2018 – Many eye diseases, including diabetic retinopathy and macular degeneration, exhibit an increased permeability of blood vessels in the macula (central) portion of the retina leading...
