by Center for Genomic Regulation Mice with a deletion in the pancreas agenesis enhancer do not express PTF1A (green) in embryonic multipotent pancreatic progenitors, leading to underdeveloped pancreas and insulin-deficient diabetes. Immunofluorescence of embryonic pancreatic buds from control (left) and enhancer-deleted (right) mice stained for PTF1A (green), PDX1 (red), glucagon (blue). Credit: Miguel Angel Maestro/Developmental...
