by Tokyo Medical and Dental University Supercomputer-based dynamic molecular network analysis predicted HMGB1-TLR4 induced signal as the most important target of two major neurodegenerative dementias. The prediction was verified by significant phenotypic and pathological improvements of four types of mouse model of frontotemporal lobar degeneration treated by anti-HMGB1 antibody. Credit: Department of Neuropathology, TMDU Dementia...
by Okinawa Institute of Science and Technology PCA of 33 AD or 6 selected dementia-related compounds showed significant differences between patients with dementia and HE subjects. Blood data of dementia and HE subjects were subjected to PCA. (A) A PCA plot using abundances of 33 (7 increased and 26 decreased) dementia-related compounds. Dementia and HE subjects...
The Asian community is very diverse, so it is difficult to draw conclusions on how different genetic, cultural, and environmental factors contribute to dementia in these populations. One 2018 studyTrusted Source noted the Filipino community had the most cases of dementia within the Asian population over the course of a 14-year investigation. However, the authors noted that...
IMAGE: STUDY RESULTS SHOW ELEVATED BLOOD FLOW AND IMPROVED OXYGENATION IN THE BRAIN OF PATIENTS SUFFERING FROM COGNITIVE IMPAIRMENT CREDIT: TEL AVIV UNIVERSITY (TAKEN FROM THE ARTICLE). Scientific Breakthrough: A team of investigators from Tel Aviv University has succeeded in restoring brain trauma by hyperbaric oxygen therapy (HBOT). This is the first time in the...
by Karolinska Institutet Credit: Unsplash/CC0 Public Domain A large study at Karolinska Institutet in Sweden has found a link between ADHD and dementia across generations. The study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, shows that parents and grandparents of individuals with ADHD were at higher risk of dementia than those with children...
by University of Helsinki Olfactory bulb/peduncle alpha-synuclein staining predominance categorized by LRP progression-based classification [6]. Percentages add up to 100% within each LRP progression-based classification category, meaning all the caudo-rostral cases equal 100% spread across negative, peripheral and anterior olfactory nucleus predominance for alpha-synuclein staining. Similarly, the amygdala-based category cases add up to 100% spread across the...
by Robert Burke, University of Pennsylvania Credit: CC0 Public Domain Are older adults with dementia “rehabbed to death?” This is the contention of a perspective published in the New England Journal of Medicine, describing the downward cycle of rehospitalization leading to death that many of these older adults experience. Hospitalization is a particularly significant event for older...
by Kyoto University Karyotype analysis of the iPSC clones. Credit: DOI: 10.1038/s41598-021-96697-7 Down syndrome is mostly known for the learning disabilities it causes, but patients typically suffer from a wide number of ailments. One is the early onset of Alzheimer’s disease. Using iPS cells from Down syndrome patients, a new study by CiRA researchers suggests that the molecular...
A proinflammatory diet, as measured by the dietary inflammatory index (DII), is associated with increased risk of all-cause dementia, although not Alzheimer’s disease, according to a new analysis of longitudinal data from the Framingham Heart Study Offspring Cohort. Dr Debora Melo van Lent The lack of an association with Alzheimer’s disease was a surprise because amyloid-beta prompts microglia and...
by Sandrine Thuret, King’s College London Credit: CC0 Public Domain New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that both diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the brain produces new brain cells) long...
