GOETHE UNIVERSITY FRANKFURT FRANKFURT. The specific or acquired immune system of vertebrates is a powerful weapon against pathogens and pathologically altered body cells. Here, T cells play a special role. After activation, they can systematically kill off target cells that have degenerated or are infected with a virus. They carry a receptor on their surface...
Tag: <span>Dendritic Cells</span>
Post
Vitamin E can boost immunotherapy responses by reinvigorating dendritic cells
by University of Texas M. D. Anderson Cancer Center Credit: Unsplash/CC0 Public Domain Combining a retrospective analysis of clinical records with in-depth laboratory studies, researchers at The University of Texas MD Anderson Cancer Center have discovered that vitamin E can enhance immunotherapy responses by stimulating the activity of dendritic cells in the tumor. The findings...
Post
Oncotarget: Activation of plasmacytoid dendritic cells promotes AML-cell fratricide
IMPACT JOURNALS LLC IMAGE: IFNβ-induced AML-cell cytotoxicity is enhanced with anti-CD38 antibody daratumumab. (A-C) AML cell lines (MV-411, n = 9 experiments and OCI-AML3, n = 7 experiments) and primary AML apheresis samples (n = 3) were treated with or without 1000 U/mL IFNβ for 24 h and then incubated with opsonized sheep red blood...
Post
153 years after discovery of the immune system’s dendritic cells, scientists uncover a new subset
by Delthia Ricks , Medical Xpress Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. Credit: National Institutes of Health (NIH) When pathogens invade or tumor cells emerge, the immune system is alerted by danger signals that summon a key battalion of first responders,...
Post
Important factor in the development of dendritic cells identified
by Medical University of Vienna Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. Credit: National Institutes of Health (NIH) The human immune system comprises functionally specialized cellular defense mechanisms that protect the body against disease. These include the dendritic cells. Their main function is...
Post
Scientists identify a mechanism through which dendritic cells improve their antiviral and immunotherapy strategies
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Left A dendritic cell presents foreign material to a T lymphocyte, preparing it to mount an effective immune response to it. Right Through genetic and epigenetic changes, this process also prepares the dendritic cell to meet future threats to the organism by increasing its tropism toward...
Post
Diseased cell fragments burst from pockets in immune cells to activate response
by The Francis Crick Institute Dendritic cells are white blood cells that get their name from their tree-like shape. Credit: The Francis Crick Institute Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new...
Post
Intranasal vaccine platform has potential for more effective vaccines, fewer side effects
by University of Chicago Medical Center The ongoing COVID-19 pandemic is shining a bright spotlight on vaccine development. As numerous vaccines race through clinical trials, physicians and researchers continue to work on developing new vaccine technologies to generate the most effective vaccines with the fewest side effects. A new proof-of-concept study by researchers at the...
Post
COULD TINY ‘DISTRACTING’ RODS SAVE COVID-19 PATIENTS?
White blood cells called neutrophils may be central to the immune system overreaction that can kill COVID-19 patients. New research finds that rod-shaped particles can take them out of circulation. The top cause of death for COVID-19 patients echoes the way the 1918 influenza pandemic killed: their lungs fill with fluid and they essentially drown....
Post
Successful anti-PD-1 therapy requires interaction between CD8+ T cells and dendritic cells
A team led by a Massachusetts General Hospital (MGH) investigator has found that successful cancer immunotherapy targeting the PD-1 molecule requires interaction between cytotoxic CD8+ T cells, which have been considered the primary therapeutic target, and dendritic cells, critical activators of T cell response. The report that will be appearing in the journal Immunity and...
- 1
- 2