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Cancer cells found to replace depleted tryptophan using phenylalanine substitutants
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Cancer cells found to replace depleted tryptophan using phenylalanine substitutants

by Bob Yirka, Medical Xpress Substitutants are presented at the cell surface and activate T cells. Credit: Nature (2022). DOI: 10.1038/s41586-022-04499-2 An international team of researchers has found that some cancer cells are able to make up for a loss of tryptophan by conducting codon reassignments that allow for the production of phenylalanine “substitutants” (a word they...